Flashcards in Immunology - Principles Deck (16):
Which cytokines are secreted by Th2s?
IL-4 - Promotes IgG and IgE class switching
IL-5 - Promotes IgA class switching; stimulates division and differentiation of eosinophils
IL-10 - Inhibits differentiation of T cell precursors into Th1s
Which cytokines are secreted by Th1s?
IL-2 - Provides the second signal for CTL activation
IFNy - Activates macrophages; inhibits differentiation of T cell precursors into Th2s
Which 2 signals activate naive T cells?
1. Binding between antigen presented on MHC Class I and TCR
2. Binding between B7 on the APC and CD28 on the naive T cell
Which 2 signals activate B cells / class switching?
1. Binding between foreign antigen presented on MHCII and the TCR
2. Binding between CD40L on the APC and CD40 on the B cell
Which 2 signals activate CTLs?
1. Binding between CD8 on CTL and MHC1 on virus-infected cell
2. Binding of IL-2 from Th1s
Which cytokines are produced by Tregs?
IL-10 - Inhibits differentiation of Th1s
TGF-B - Inhibits differentiation of Th1s
Endogenous pyrogen secreted by macrophages; causes fever and acute inflammation, activates endothelium to express adhesion molecules
Endogenous pyrogen secreted by macrophages; causes fever and stimulates production of acute-phase proteins
Secreted from all T cells; stimulates growth of helper, cytotoxic, and regulatory T cells
IL-2 transcription is down-regulated by cyclosporine (immunosuppressant); conversely, IL-2 is used in the treatment of certain cancers
CD28 / B7
CD28 on naive T cells binds B7 on antigen presenting cells; this interaction represents the second signal necessary for T cell interaction
CD40 / CD40L
CD40 on B cells binds CD40L on Th cells; this interaction activates the B cell to undergo activation and class switching
What cell surface markers are expressed by NK cells?
CD16 - Binds FC of IgG
CD56 - unique marker for NK
Which bacteria are catalase positive?
Which complement components trigger histamine release?
Which vaccines are live attenuated?