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Flashcards in Immunology - Principles Deck (16):
1

Which cytokines are secreted by Th2s?

IL-4 - Promotes IgG and IgE class switching

IL-5 - Promotes IgA class switching; stimulates division and differentiation of eosinophils

IL-10 - Inhibits differentiation of T cell precursors into Th1s

2

Which cytokines are secreted by Th1s?

IL-2 - Provides the second signal for CTL activation

IFNy - Activates macrophages; inhibits differentiation of T cell precursors into Th2s

3

Which 2 signals activate naive T cells?

1. Binding between antigen presented on MHC Class I and TCR

2. Binding between B7 on the APC and CD28 on the naive T cell

4

Which 2 signals activate B cells / class switching?

1. Binding between foreign antigen presented on MHCII and the TCR

2. Binding between CD40L on the APC and CD40 on the B cell

5

Which 2 signals activate CTLs?

1. Binding between CD8 on CTL and MHC1 on virus-infected cell

2. Binding of IL-2 from Th1s

6

Which cytokines are produced by Tregs?

IL-10 - Inhibits differentiation of Th1s
TGF-B - Inhibits differentiation of Th1s

7

IL-1

Endogenous pyrogen secreted by macrophages; causes fever and acute inflammation, activates endothelium to express adhesion molecules

8

IL-6

Endogenous pyrogen secreted by macrophages; causes fever and stimulates production of acute-phase proteins

9

IL-2

Secreted from all T cells; stimulates growth of helper, cytotoxic, and regulatory T cells

IL-2 transcription is down-regulated by cyclosporine (immunosuppressant); conversely, IL-2 is used in the treatment of certain cancers

10

CD28 / B7

CD28 on naive T cells binds B7 on antigen presenting cells; this interaction represents the second signal necessary for T cell interaction

11

CD40 / CD40L

CD40 on B cells binds CD40L on Th cells; this interaction activates the B cell to undergo activation and class switching

12

What cell surface markers are expressed by NK cells?

CD16 - Binds FC of IgG

CD56 - unique marker for NK

13

Which bacteria are catalase positive?

Pseudomonas
Listeria
Aspergillus
Candida
E. coli
Staph aureus
Serratia

14

Which complement components trigger histamine release?

C3a
C5a

15

Which vaccines are live attenuated?

MMR
Polio (Sabin)
Influenza (intranasal)
Varicella
Yellow fever

16

Which vaccines are killed/inactivated?

Rabies
Influenza (injected)
Polio (Salk)
hav