Immunopathology - Week 10 - Immune Response to Parasite

Question 1

What is introduced into the bloodstream by an infected female mosquito?

Answer 1

Sporozites.

Question 2

What is the cycle of sporozoites entering the body?

Answer 2

Sporozoites -> to the liver -> proliferate -> merozoites -> released to the circulation -> infect red
blood cells (RBC) -> damage the RBC

Question 3

Some of the merozoites differentiate into what?

Answer 3

Male and female gametocytes.

Question 4

In the Immune response involved in clearing malaria, what blocks the invasion of
sporozoites into liver cells?

Answer 4

Antibodies.

Question 5

In the Immune response involved in clearing malaria, what cells inhibit parasite
development in hepatocytes?

Answer 5

IFN-y and CD8 T.

Question 6

In the Immune response involved in clearing malaria, what blocks invasion of
merozoites into RBC?

Answer 6

Antibodies.

Question 7

In the Immune response involved in clearing malaria, what type of cell are capable of directly killing parasitized cells, whether in the RBCs or hepatocytes by cytotoxicity?

Answer 7

Natural Killer (NK) Cells.