Immunosuppressants Flashcards Preview

Pharmacology > Immunosuppressants > Flashcards

Flashcards in Immunosuppressants Deck (32):
1

Tacrolimus

Calcineurin Inhibitor
Inhibit NFAT, a downstream contributor to IL-2 synthesis
IV or oral - CYP3A metabolism
Nephrotoxicity, Neurotoxicity, Hyperglycemia

2

First line immunosuppressive

Prednisone & Prednisolone

3

Organ transplantation
GvHD
Autoimmune disorders

Calcineurin Inhibitors

4

Fusion protein that recognizes CD2
Plaque psoriasis

Alefacept

5

Inhibits IMP Dehydrogenase in S Phase and inhibits purine synthesis
Organ Transplantation
SE: Myelosuppression, GI upset

Mycophenolate Mofetil

6

Inhibit NF-kB

Prednisone & Prednisolone

7

Etanercept, Adalimumab, Golimumab, Infliximab, Certolizumab

TNF-alpha/beta blockers
Rheumatoid Arthritis
SE: Susceptible to infection, Infusion reaction

8

TNF-alpha/beta blockers

Etanercept, Adalimumab, Golimumab, Infliximab, Certolizumab
Rheumatoid Arthritis

9

Inhibits mTOR halting cell at G1-S Checkpoint
Organ Transplantation
SE: Myelosuppression, Hyperlipidemia

Rapamycin (Sirolimus)

10

Purine analog (6-Thio-IMP)

Azathioprine

11

Azathioprine

Purine analog (6-Thio-IMP)
Organ transplantation, RA, Induction/maintenance of remission of ulcerative colitis
SE: Myelosuppression, Hepatic Toxicity

12

Anti-Proliferative/Anti-metabolic

Rapamycin (Sirolimus)
Mycophenolate Mofetil
Azathioprine
Methotrexate
Cyclophosphamide

13

Calcineurin Inhibitors
Inhibit NFAT, a downstream contributor to IL-2 synthesis
Oral - CYP3A metabolism
Nephrotoxicity

Cyclosporin

14

SE: Protein catabolism, Central adiposity, Hyperglycemia, Osteoporosis, Adrenal Insufficiency

Prednisone & Prednisolone

15

Antithymocyte Globulin: (ATG and ALG)

Ab that recognizes a wide variety of antigens on T cells
Acute transplant rejection
SE: Fever, chills, potentially hypotension
Leukopenia, thrombocytopenia, HAMA Reaction

16

Muromonab-CD3

Murine monoclonal antibody directed against the human CD3 molecule
Acute allograft rejection
SE: Cytokine Release syndrome, HAMA

17

Rapamycin (Sirolimus)
Mycophenolate Mofetil
Azathioprine
Methotrexate
Cyclophosphamide

Anti-Proliferative/Anti-metabolic

18

Mycophenolate Mofetil

Inhibits IMP Dehydrogenase in S Phase and inhibits purine synthesis
Organ Transplantation
SE: Myelosuppression, GI upset

19

Glucocorticoids

Prednisone & Prednisolone

20

Cyclosporin

Calcineurin Inhibitor
Inhibit NFAT, a downstream contributor to IL-2 synthesis
Oral - CYP3A metabolism
Nephrotoxicity

21

Rapamycin (Sirolimus)

Inhibits mTOR halting cell at G1-S Checkpoint
Organ Transplantation
SE: Myelosuppression, Hyperlipidemia

22

Murine monoclonal antibody directed against the human CD3 molecule
Acute allograft rejection
SE: Cytokine Release syndrome, HAMA

Muromonab-CD3

23

Alkylating agent that cross-links a number of cellular macromolecules with DNA

Cyclophosphamide

24

Cyclophosphamide

Alkylating agent that cross-links a number of cellular macromolecules with DNA
Organ rejection, Autoimmune disorders, Wegener's Granulomatosus
SE: Suppression of all rapidly growing tissue, Pancytopenia, GI upset

25

Organ transplantation, RA, Induction/maintenance of remission of ulcerative colitis

Azathioprine

26

Rho(D) Immune Globulin

Binds Rho antigens and prevents maternal immune system from sensitizing to them
Rhesus incompatibility

27

Prednisone & Prednisolone

Transactivation - bind to steroid hormone receptors, translocate to the nucleus, and promote synthesis of regulatory peptides
Associated with Adverse Effects

Transrepression - bind to steroid hormone receptors,translocate to the nucleus, and suppress synthesis of NFkB responsive elements

28

Ab that recognizes a wide variety of antigens on T cells
Acute transplant rejection

Antithymocyte Globulin: (ATG and ALG)

29

Calcineurin Inhibitor
Inhibit NFAT, a downstream contributor to IL-2 synthesis
IV or oral - CYP3A metabolism
Nephrotoxicity, Neurotoxicity, Hyperglycemia

Tacrolimus

30

Alefacept

Fusion protein that recognizes CD2
Plaque psoriasis

31

Methotrexate

Inhibits DHF Reductase
Remission of IBD, RA, GvHD
SE: Myelosuppression, Hepatic Toxicity

32

Inhibits DHF Reductase
Remission of IBD, RA, GvHD
SE: Myelosuppression, Hepatic Toxicity

Methotrexate