Immunosuppressants

Question 1

Tacrolimus

Answer 1

Calcineurin Inhibitor
Inhibit NFAT, a downstream contributor to IL-2 synthesis
IV or oral - CYP3A metabolism
Nephrotoxicity, Neurotoxicity, Hyperglycemia

Question 2

First line immunosuppressive

Answer 2

Prednisone & Prednisolone

Question 3

Organ transplantation
GvHD
Autoimmune disorders

Answer 3

Calcineurin Inhibitors

Question 4

Fusion protein that recognizes CD2

Plaque psoriasis

Answer 4

Alefacept

Question 5

Inhibits IMP Dehydrogenase in S Phase and inhibits purine synthesis
Organ Transplantation
SE: Myelosuppression, GI upset

Answer 5

Mycophenolate Mofetil

Question 6

Inhibit NF-kB

Answer 6

Prednisone & Prednisolone

Question 7

Etanercept, Adalimumab, Golimumab, Infliximab, Certolizumab

Answer 7

TNF-alpha/beta blockers
Rheumatoid Arthritis
SE: Susceptible to infection, Infusion reaction

Question 8

TNF-alpha/beta blockers

Answer 8

Etanercept, Adalimumab, Golimumab, Infliximab, Certolizumab

Rheumatoid Arthritis

Question 9

Inhibits mTOR halting cell at G1-S Checkpoint
Organ Transplantation
SE: Myelosuppression, Hyperlipidemia

Answer 9

Rapamycin (Sirolimus)

Question 10

Purine analog (6-Thio-IMP)

Answer 10

Azathioprine

Question 11

Azathioprine

Answer 11

Purine analog (6-Thio-IMP)
Organ transplantation, RA, Induction/maintenance of remission of ulcerative colitis
SE: Myelosuppression, Hepatic Toxicity

Question 12

Anti-Proliferative/Anti-metabolic

Answer 12

Rapamycin (Sirolimus)
Mycophenolate Mofetil
Azathioprine
Methotrexate
Cyclophosphamide

Question 13

Calcineurin Inhibitors
Inhibit NFAT, a downstream contributor to IL-2 synthesis
Oral - CYP3A metabolism
Nephrotoxicity

Answer 13

Cyclosporin

Question 14

SE: Protein catabolism, Central adiposity, Hyperglycemia, Osteoporosis, Adrenal Insufficiency

Answer 14

Prednisone & Prednisolone

Question 15

Antithymocyte Globulin: (ATG and ALG)

Answer 15

Ab that recognizes a wide variety of antigens on T cells
Acute transplant rejection
SE: Fever, chills, potentially hypotension
Leukopenia, thrombocytopenia, HAMA Reaction

Question 16

Muromonab-CD3

Answer 16

Murine monoclonal antibody directed against the human CD3 molecule
Acute allograft rejection
SE: Cytokine Release syndrome, HAMA

Question 17

Rapamycin (Sirolimus)
Mycophenolate Mofetil
Azathioprine
Methotrexate
Cyclophosphamide

Answer 17

Anti-Proliferative/Anti-metabolic

Question 18

Mycophenolate Mofetil

Answer 18

Inhibits IMP Dehydrogenase in S Phase and inhibits purine synthesis
Organ Transplantation
SE: Myelosuppression, GI upset

Question 19

Glucocorticoids

Answer 19

Prednisone & Prednisolone

Question 20

Cyclosporin

Answer 20

Calcineurin Inhibitor
Inhibit NFAT, a downstream contributor to IL-2 synthesis
Oral - CYP3A metabolism
Nephrotoxicity

Question 21

Rapamycin (Sirolimus)

Answer 21

Inhibits mTOR halting cell at G1-S Checkpoint
Organ Transplantation
SE: Myelosuppression, Hyperlipidemia

Question 22

Murine monoclonal antibody directed against the human CD3 molecule
Acute allograft rejection
SE: Cytokine Release syndrome, HAMA

Answer 22

Muromonab-CD3

Question 23

Alkylating agent that cross-links a number of cellular macromolecules with DNA

Answer 23

Cyclophosphamide

Question 24

Cyclophosphamide

Answer 24

Alkylating agent that cross-links a number of cellular macromolecules with DNA
Organ rejection, Autoimmune disorders, Wegener’s Granulomatosus
SE: Suppression of all rapidly growing tissue, Pancytopenia, GI upset

Question 25

Organ transplantation, RA, Induction/maintenance of remission of ulcerative colitis

Answer 25

Azathioprine

Question 26

Rho(D) Immune Globulin

Answer 26

Binds Rho antigens and prevents maternal immune system from sensitizing to them Rhesus incompatibility

Question 27

Prednisone & Prednisolone

Answer 27

Transactivation - bind to steroid hormone receptors, translocate to the nucleus, and promote synthesis of regulatory peptides Associated with Adverse Effects Transrepression - bind to steroid hormone receptors,translocate to the nucleus, and suppress synthesis of NFkB responsive elements

Question 28

Ab that recognizes a wide variety of antigens on T cells | Acute transplant rejection

Answer 28

Antithymocyte Globulin: (ATG and ALG)

Question 29

Calcineurin Inhibitor Inhibit NFAT, a downstream contributor to IL-2 synthesis IV or oral - CYP3A metabolism Nephrotoxicity, Neurotoxicity, Hyperglycemia

Answer 29

Tacrolimus

Question 30

Alefacept

Answer 30

Fusion protein that recognizes CD2 | Plaque psoriasis

Question 31

Methotrexate

Answer 31

Inhibits DHF Reductase Remission of IBD, RA, GvHD SE: Myelosuppression, Hepatic Toxicity

Question 32

Inhibits DHF Reductase Remission of IBD, RA, GvHD SE: Myelosuppression, Hepatic Toxicity

Answer 32

Methotrexate