Infections in pregnancy Flashcards

1
Q

How does chicken pox present?

A

Fever
Malaise
Itchy vesicular rash

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2
Q

How is chicken pox spread?

A

Respiratory droplets

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3
Q

What is the period of infectivity for chicken pox?

A

48h before the rash develops until all the lesions have crusted over (5-7 days after rash starts usually)

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4
Q

How does chicken pox affect children?

A

Usually harmless and self-limiting

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5
Q

What are the risks of contracting chicken pox as an adult?

A

Hepatitis
Encephalitis
Pneumonitis
Greater risk in immunocompromised

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6
Q

When is there a risk of congenital infection?

A

When a non-immune pregnant woman is exposed within the first 28 weeks of pregnancy

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7
Q

Does fetal varicella syndrome increase risk of miscarriage?

A

No

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8
Q

How does fetal varicella syndrome present?

A

Skin scarring
Congenital eye abnormalities
Hypoplasia of ipsilateral limbs
Neuro abnormalities

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9
Q

What is the risk of congenital infection if the mother is exposed in the last 4 weeks of pregnancy?

A

Significant

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10
Q

What test is taken if a woman who is unsure if she is immune has been exposed to chicken pox?

A

Serum IgG to check her immunity status
If IgG positive, we just need to reassure
If IgG negative then VZ immunoglobulin should be offered asap

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11
Q

How is severe VZ infection managed in pregnant women?

A

IV aciclovir

Admit to hospital

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12
Q

What are some other names for parvovirus b19?

A

Slapped cheek disease
Fifth disease
Erythema infectiosum

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13
Q

How is parvovirus b19 spread?

A

Respiratory droplets

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14
Q

How does parvovirus b19 present in children?

A

Fever
Rash
Erythema of cheeks

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15
Q

How does parvovirus b19 present in adults?

A

Usually asymptomatic

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16
Q

Is there a vaccine available for parvovirus b19?

A

No

17
Q

How can parvovirus b19 infection affect pregnancy?

A

Fetal anaemia
Cardiac failure
Fetal death
Hydrops fetalis

18
Q

What is hydrops fetalis?

A

A condition in the fetus characterised by an accumulation of fluid, or oedema, in at least two fetal compartments

19
Q

What is the critical period for infection of parvovirus b19 during pregnancy?

A

12-20 weeks

20
Q

How is parvovirus b19 infection in pregnancy managed?

A

Serum IgG taken

If positive weekly scans are offered to monitor fetal abnormalities

21
Q

What causes toxoplasmosis?

A

Toxoplasmogondii

22
Q

How is toxoplasmosis usually contracted?

A

Infected cat faeces

Undercooked meats

23
Q

How does toxoplasmosis present in adults?

A

Usually asymptomatic

May cause flu like symptoms (Sore throat, coryza, arthralgia)

24
Q

Can toxoplasmosis increase risk of miscarriage or intrauterine death?

A

Yes

25
Q

Does HIV increase risk of congenital abnormalities?

A

No

26
Q

What are some risks associated with HIV in pregnancy?

A

Pre-eclampsia
Preterm delivery
Low birth weight

27
Q

What are the aims of combined ant-retroviral treatment (cART)?

A

Reduce viral load
Reduce risk of vertical treatment
Improve mother’s health

28
Q

Does breastfeeding increase or decrease the chance of vertical transmission of HIV?

A

Increase

29
Q

What are some measurements taken to check up on HIV risk throughout pregnancy?

A

CD4 count
LFTs whilst on cART
HIV viral load

30
Q

What does low viral load indicate?

A

Vaginal birth supported

31
Q

How is Hep B usually spread?

A

Vertical transmission

Blood and other body fluids

32
Q

What are some conditions which Hep B contraction at birth could from mother could predispose you to?

A

Liver cirrhosis

Hepatocellular cancer

33
Q

How are mothers with chronic HBV and high viral load managed?

A

Tenofivir monotherapy in 3rd trimester to reduce risk of transmission

34
Q

How are babies managed when mother has Hep B?

A

Hep B immunoglobulins at birth

Accelerated immunisation schedule

35
Q

Does breastfeeding increase Hep C transmission?

A

No

36
Q

Which pathogen causes syphilis?

A

Treponema pallidum

37
Q

Can syphilis be cured?

A

Yes

IM penicillin course

38
Q

How may syphilis be transmitted from mother to child?

A

Trans-placental

Exposure to lesion at birth

39
Q

When can congenital syphilis present?

A

Usually first 2 years of life

Most develop symptoms within 5 weeks