Inflammation

Question 1

5 cardinal signs

Answer 1

Pain
Redness
Heat
Swelling
Loss function

Question 2

Key stages tissue Healing

Answer 2

1. Bleeding (10 mins)
2. Acute Inflammation (2-2 weeks)
3. Proliferation (5-7 days)
4. Remodling (3-12 months)

Question 3

Bleeding phase

Answer 3

• last 10 mins
• vasocontriction happens immediately to reduce blood loss
• short term platelets + clotting factors create a plug

Question 4

Inflammation

Answer 4

• following bleeding phase, inflammatory response occurs
• blood vessels dilate, increasing blood flow to the area - brings immune cells (neutrophils + macrophages) to the site of injury
  -These clear cell debris + pathogens, while also releasing signaling molecules that facilitate healing

Question 5

Proliferation

Answer 5

• 3 days - 3 weeks
• new granulation tissue forms
• fibroblasts proliferate + synthesize collagen + extracellular matrix, providing structural support
• formation new blood cells occur ensuring new tissue recieves adequate nutrients + oxygen
• epithelial cells may also proliferate to establish the skin barrier if injury is superficial

Question 6

Remodling