Inflammation #6: SLE and Gout Flashcards Preview

Musculoskeletal Disorders and Pain Management > Inflammation #6: SLE and Gout > Flashcards

Flashcards in Inflammation #6: SLE and Gout Deck (30):
1

What does SLE affect? (5)

-skin
-joints
-heart
-blood
-kidneys

2

What type of immune complex-mediated hypersensitivity is SLE?

type III

3

What is discoid lupus?

skin rash ONLY

4

(Myeloid)Neutrophils can DIRECTLY activate B cells by releasing?

BLyS (B-lymphocyte stimulator)

5

Myeloid cells are precursors to _______

neutrophils

6

Hydroxychloroquine (3)

Plaquenil
-used to treat SLE
-antimalarial

7

Hydroxychloroquine is a _____ base.

weak

8

Since Hydroxychloroquine is a weak base, what does it allow to happen?

it easily penetrate the plasma membrane of macrophages and dendritic cells--> this accumulates in the lysosomes--> increase in the pH from 4-6

9

The higher pH in the lysosome from the increase of hydroxychloroquine causes what to happen? (3)

INHIBITS the interaction between:
-AUTOANTIGENS
-Class II MHC molecules
-Subsequent antigen presentation at the cell surface

10

What is gout?

heterogeneous disease resulting from deposition into tissues of MONO-sodium rate crystals

11

What is the term used to describe elevated levels of uric acid in the blood?

hyperuricemia

12

The treatment of gout is directed at TWO major phases of the disease what are those?

- Acute Attacks of gout
- Prophylactic treatment, preventing attacks

13

What are the major clinical manifestations of GOUT? (4)

-recurrent attacks of acute inflammatory arthritis
-accumulation of uric acid (TOPHI)
-formation of uric acid stones
-renal impairment

14

renal impairment in patients with gout is known as?

gouty nephropathy

15

formation of uric acid STONES

urolithiasis

16

What is the primary JOINT attacked in GOUT?

metatarsophalangeal joint

17

What is Podagra?

a painful condition of the big toe caused by gout

18

There is a correlation between development of GOUT and plasma levels _______

greater than 7 mg/dL

19

The real reason for deposition in joints for patients with gout is UNKNOWN, but some of the hypothetical reasons include? (2)

-less soluble at low temp
-lower pH

20

The deposition of monosodium rate crystals can lead to ____ and _____

fever and leukocytosis

21

The affected joints in GOUT presents with? (3)

-intense pain
-erythema AND warmth
-inflammation

22

Where is uric acid SYNTHESIZED?

in the liver

23

T/F Humans lack URICAS that degrade uric acid to allantoin

TRUE

24

The URATE load in GOUT is derived from? (2)

-catabolism of dietary source (purines)
-breakdown of endogenous purine nucleotides

25

What are the 3 parts of the nucleotide?

-pentose sugar
-phosphate linker
-purine or pyrimidine

26

URATE elimination in humans is mainly via

the kidneys (2/3) and the GI tract (1/3)

27

What can lead to immune dysregulation in SLE? (3)

-genetic predisposition
-environmental triggers
-hormonal abnormalities

28

BLyS is present in _____ B cells

MATURE

29

Belimumab recognizes and binds to _____, inhibits stimulation of B cells... which eventually leads to

BLyS; B cells can undergo normal process of apoptosis

30

The deposition of the urate crystals can lead to .....

fever and leuocytosis