Inflammatory Bowel Disease (Quiz 2)

Question 1

what two diseases does IBD include

Answer 1

• ulcerative colitis

- Chron’s disease

Question 2

cryptitis, crypt abscess and ulceration are indicative of what condition

Answer 2

• active colitis

Question 3

what is present in active colitis

Answer 3

• neutrophils

Question 4

what is it called when neutrophils are present within crypt epithelium

Answer 4

• cryptitis

Question 5

what is it called when neutrophils are within the crypt lumen

Answer 5

• crypt abscess

Question 6

what is it called when there is inflammatory disruption of mucosal surface

Answer 6

• ulceration

Question 7

what is altered crypt architecture and increased lamina propria chronic inflammation indicative of

Answer 7

• chronic colitis

Question 8

what encompasses altered crypt architecture

Answer 8

• crypt disarray - not uniform in size and distribution
• crypt dropout - loss of crypts (atrophy)
• crypt branching

Question 9

what is chronic colitis with superimposed active colitis

Answer 9

• chronic active colitis

Question 10

what is it called when there is an increased number of plasma cells between crypt bases and muscularis mucosae

Answer 10

• basal plasmacytosis

Question 11

what is IBD characterized by

Answer 11

• chronic recurrent inflammation in GI tract

Question 12

racial and ethnic populations more likely to get IBD

Answer 12

• white and Jewish

Question 13

smoking effect on ulcerative colitis

smoking effect on Chrons

Answer 13

• decreased disease activity

- increased disease activity

Question 14

appendectomy effect on ulcerative colitis

appendectomy effect on Chrons

Answer 14

• protective

- no role`

Question 15

potential causes of IBD

Answer 15

• genetic susceptibility
• immune dysregulation
• environmental factors

Question 16

ulcerative colitis is an inflammatory disease where

Answer 16

• limited to the colon

Question 17

inflammation in ulcerative colitis is

Answer 17

• continuous

Question 18

ulcerative colitis always involves the

Answer 18

• rectum

Question 19

ulcerative colitis inflammation mainly involves which layer

Answer 19

• mucosa

- superficial ulceration and exudate

Question 20

big symptoms of ulcerative colitis

Answer 20

• intense diarrhea (bloody)
• urgency
• tenesmus

Question 21

which ulcerative colitis is of the rectum only

Answer 21

• proctitis

Question 22

which ulcerative colitis is up to the splenic fixture

Answer 22

• left sided colitis

Question 23

which ulcerative colitis is beyond the splenic fixture

Answer 23

• extensive/pancolitis

Question 24

important complications of ulcerative colitis

Answer 24

• toxic megacolon leading to perforation and sepsis

- colon cancer

Question 25

gross features of ulcerative colitis

Answer 25

- hemorrhagic granular mucosa | - pseudopolyps

Question 26

what are the histologic features of ulcerative colitis

Answer 26

- lymphoplasmacytic infiltrate that expands lamina proper - crypt abnormalities of chronic inflammation - inflammation limited to mucosa

Question 27

Chron disease is present in what part of the GI tract most common place

Answer 27

- any part of the GI tract | - terminal ileum

Question 28

inflammation in Chron disease can be characterized as

Answer 28

- discontinuous/patchy

Question 29

gross features of lesions in Chron disease

Answer 29

- segmental appearance - skip lesions - Cobblestoning - fat wrapping

Question 30

inflammation in Chron disease affects what portion of the bowel wall

Answer 30

- full thickness of bowel wall

Question 31

symptoms of Chron disease

Answer 31

- diarrhea - abdominal pain - growth retardation in children

Question 32

complications of Chron disease

Answer 32

- inflammation - stricture/obstruction - fistulization

Question 33

best diagnostic tool for ulcerative colitis and Chron's disease

Answer 33

- Colonoscopy

Question 34

important findings in histology of Chron disease

Answer 34

- granulomas within mucosa or deeper in bowel wall

Question 35

extra-intestinal manifestations of IBD

Answer 35

- skin - joints - eyes - mouth ulcerations

Question 36

skin manifestations of IBD

Answer 36

- erythema nodosum - cutaneous Chron disease - pyoderma gangrenosum