Flashcards in Integration of metabolism Deck (6)
How is blood glucose concentration controlled after you have had a meal?
-Increased secreation of insulin from pancreatic islets
-increased glucose uptake by liver- stored as glycogen or used in glycolysis to produce acetyl-CoA (used for fatty acid synthesis)
-Increased glucose uptake and glycogen synthesis in muscles
-Increased triglyceride synthesis in adipose tissue
-Increase use of metabolic intermeadiates throughout the body due to general stimulatory effect on synthesis and growth
What happens to excess glucose in the liver
increased glucose uptake by liver- stored as glycogen or used in glycolysis to produce acetyl-CoA (used for fatty acid synthesis)
Which mechanism control blood glucose concentration after a meal when your blood glucose conc is dropping?
-Increased glucagon secreation
-glucose production in liver by gluconeogenesis and glycogenolysis
-utilisation of fatty acid breakdown as an alternative dor ATP production
What effects does adrenaline have when yur blood glucose conc falls?
- liver-glycogenolysis and gluconeogenesis
-skeletal muscle- same as liver
adipose tissue- fat lipolysis to provide other tissues with alternative substrates
What happens to the body after prolonged fasting ( can no longer be covered by glycogen reserves)
-Adipose tissues begin to hydrolyse triglycerides to provide fatty acids for metabolism
-TCA cycle intermeadiates are reduced in amount to provide substrates for gluconeogenesis
-Protein breakdown provides amino acids for gluconeogenesis
-Ketone bodies are produced from fatty acids and amino acids in liver to substitute, partially, the brains requirements for glucose.