Metabolic pathways and ATP production I Flashcards Preview

Year1-Mubarak-Metabolism > Metabolic pathways and ATP production I > Flashcards

Flashcards in Metabolic pathways and ATP production I Deck (21)
Loading flashcards...
1

Sketch a cartoon of the 3 stages of cellular metabolism that convert food to waste products, identify the cellular location of each stage?

add pic

2

List the first 3 steps for glycolysis?

add pic

3

List steps 4 to 5 for glycolysis?

add pic

4

List steps 6 to 9 for Glycolysis?

add pic

5

What is step 10 for glycolysis?

add pic

6

What are the two main concepts for glycolysis?

Formation of a High Energy Compound Splitting of a High Energy Compound

7

What is the net result of glycolysis?

2 ATP, 2 NADH, and 2 pyruvate

8

What is substrate level phosphorylation?

Substrate-level phosphorylation can be defined as the production of ATP by the direct transfer of a high-energy phosphate group from an intermediate substrate in a biochemical pathway to ADP, such as occurs in glycolysis add pic

9

Name the 3 fates of pyruvate

Generation of acetyl CoA Alcoholic Fermentation Generation of Lactate

10

What is the reaction that converts pyruvate to lactate?

add pic

11

What is the reaction that converts Pyruvate to ethanol?

add pic

12

Why is Regeneration of NAD+ essential in anaerobic reaction?

Both alcoholic fermentation and the generation of lactate serve one common purpose: They allow NAD+ to be regenerated and thus glycolysis to continue, in conditions of oxygen deprivation.

13

What can elevated levels of Lactate dehydrogenase be used to diagnose?

Lactate Dehydrogenase as a Diagnostic Tool stroke heart attack liver disease (e.g. hepatitis) muscle injury muscular dystrophy pulmonary infarction LDH is present in many body tissues, especially the heart, liver, kidney, skeletal muscle, brain blood cells and lungs. LDH catalyses the inter-conversion of pyruvate and lactate.

14

In muscle, the amount of ATP needed during exercise is only enough to sustain contraction for around one second. How does the body overcome this problem?

large reservoir of creatine phosphate

15

Write the reaction which converts creatine phophate to creatine?

add pic

16

How can creatine phosphate be used as a diagnostic tool?

When a muscle is damaged, creatine kinase leaks into the bloodstream. Either total levels of creatine kinase or the tissue specific isoform can be measured to help to determine which tissue has been damaged

17

What elevated levels of creatine phosphate be used to diagnose?

diagnose myocardial infarction (heart attack) determine the extent of muscular disease evaluate cause of chest pain help discover carriers of muscular dystrophy (Duchenne

18

What happens in the link reaction? Write down the overall reaction

add pic

19

Where does the link reaction occur?

mitachondrial matrix

20

Name the enzymes and their corresponding co-factor that makes up the pyruvate dehydrogenase complex

add pic

21

list the 5 steps in which Pyruvate Dehydrogenase complex converts pyruvate into acetyl CoA

add pic