Metabolic pathways and ATP production II Flashcards Preview

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Flashcards in Metabolic pathways and ATP production II Deck (13)
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1

Draw the krebs cycle

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2

What are the products of the TCA cycle

Each turn of the cycle produces two molecules of CO2 (waste) plus three molecules of NADH, one molecule of GTP and one molecule of FADH2.

3

What are the names of the 8 molecules in the krebs cycle.

Oxaloacetate (4C)

Citrate (6C)

Isocitrate (6C)

alpha-ketogluterate (5C)

succinyl-CoA (4C)

Succinate (4C)

Fumerate (4C)

Malate(4C)

4

Where is succinate dehydrogenase located?

It is firmly attached to the inner surface of the inner mitochondrial membrane. Here, it can communicate directly with components in the respiratory chain, as we shall see in the next lecture.

5

How many molecules of ATP is generated in the krebs cycle?

For 1 cycle.

Three ATP molecules are formed by the re-oxidation of each NADH molecule.

Two ATP molecules are formed by the re-oxidation of each FADH2 molecule.

12

 

from the Krebs Cycle:

Oxidation of 1 X acetyl CoA molecule gives 3 x NADH + 1 x FADH2 + 1x GTP = 12 ATP

6

How are amino acids converted into products that can enter the krebs cycle?

Remove the amino group from the amino acid. Transamination- The amino froup is transferred from an amino acid to a keto acid froming new pairs of amino acids and keto acids add pic

7

How does NADH, or more accurately, its high-energy electrons, cross from the cytosol into the matrix of the mitochondria ?

The Glycerol Phosphate Shuttle – skeletal muscle, brain The Malate-Aspartate Shuttle - liver, kidney and heart

8

In what organs is the The Glycerol Phosphate Shuttle found?

skeletal muscle, brain

9

In what organs is the The Malate-Aspartate Shuttle found?

liver, kidney and heart

10

State what happens during the Glycerol Phosphate shuttle?

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11

State what happens during Malate-Aspartate Shuttle?

A hydride ion (H-) is transferred from cytoplasmic NADH to oxaloacetate to give malate, a reaction catalysed by cytosolic malate dehydrogenase (MDH). Malate can be transported into the mitochondria where it is rapidly re-oxidised by NAD+ to give oxaloacetate and NADH (catalysed by mitochondrial MDH). add pic

12

What is the net reaction for NADH in the Malate-Aspartate shuttle?

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13

What is the difference between NADPH and NADH?

NADPH takes part in anabolic reactions, whereas NADH takes place in catabolic reactions.