Interactions-Table 1 Flashcards Preview

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Flashcards in Interactions-Table 1 Deck (38):
1

Question

Answer

2

Diazepam (valium)

Effects are enhanced when used in conjunction with other CNS depressants and alcohol
Cimetidine may increase diazepam plasma levels

3

Lorazepam

Effects of lorazepam will be increased when used in conjunction with other CNS depressants, alcohol, or cimetidine

4

Midazolam (Versed)

Prolonged respiratory depression when given in conjunction with other CNS depressants such as alcohol, cimetidine (Tagamet) increases plasma levels of midazolam

5

Succinylcholine (Anectine)

Effects potentiated by oxytocin, beta-blockers, and organop hospha tes
Diazepam may reduce duration of action

6

Epinephrine (Adrenalin)

May increase hypotension caused by phenothiazines, alpha and beta blockers, can be deactivated in alkaline solutions or sodium bicarbonate

7

Vasopressin

Epinephrine, heparin, alcohol, phenytoin, neostigmine, thiazide diuretics, carbamazepine

8

Lidocaine

Use caution when administered with beta blockers or procainamide as drug toxicity may result

9

Amiodarone

Increases digoxin levels and enhances pharmacological effects of procainamide, lidocaine, quinidine, and oral anticoagulants. Concurrent use of calcium channel blockers, beta blockers, fentanyl, or cimetidine may potentiate sinus bradycardia

10

Atropine Sulfate

Antihistamines, tricyclic antidepressants, procainamide can lead to the anticholinergic effects of atropine

11

Adenosine (Adenocard)

Patients taking caffeine or xanthines (aminophylline or theophylline) may require larger doses as these drugs antagonize

12

Diltiazem (Cardizem)

adenosine

13

Metoprolol (Lopressor, Toprol XL)

Patients on dipyridamole (Persantine) and carbamazepine (Tegretol) may need smaller doses of adenosine as these drugs potentiate adenosine’s effects

14

Dopamine (Intropin)

Cardiogenic shock, hemodynamically significant hypotension (systolic BP of 70 - 100 mmHg not resulting from hypovolemia), symptomatic bradycardia

15

Dobutrex (Dobutamine)

Absolute interaction with beta-blockers as they decrease dobutamine’s effectiveness. Use with extreme caution with tricyclic antidepressa nts

16

Aspirin

Suspected AMI, chest pain, or ACS

17

Nitroglycerin

May cause hypotension when used in conjunction with alcohol and antihypertensives (beta-blockers)

18

Sodium Bicarbonate (NaHCO3)

Will deactivate most catecholamines and vasopressors
Sodium bicarbonate will precipitate when used in conjunction with calcium chloride

19

Magnesium Sulfate

Can cause cardiac conduction abnormalities when used in conjunction with digitalis

20

Oxytocin

Can cause hypertension when used in conjunction with vasoconstrictors

21

Albuterol

Other sympathomimetic bronchodilators, beta-blockers. Use with extreme caution with patients on MAOIs and TCAs as potentiation may occur

22

Atroven

None

23

Methylprednisolone (Solu-medrol)

Use caution in patients on salicylates, phenytoin, rifampin, theophylline, furosemide, and thiazide diuretics

24

50% Dextrose in water (D50W or D50)

None

25

Glucagon (GlucaGen)

None Significant

26

Diphenhydramine

Potentiated by the administration of other CNS depressants, antihistamines, narcotics, and alcohol. MAOIs may prolong or intensify the anticholinergic effects

27

Haloperidol (Haldol)

Increased sedation with concomitant use of narcotic agonists, benzodiazepines, alcohol, TCAs, and antihistamines

28

Naloxone (Narcan)

May cause narcotic withdrawal in the narcotic-dependent patient so administer only enough to reverse respiratory depression

29

Furosemide (lasix)

Digitalis and lithium toxicity

30

CyanoKit

Due to incompatibilities (particulate formation), the following medications need to be run through different tubing (separate from hydroxocobolamin):
diazepam dobutamine dopamine fentanyl nitroglycerin

31

Calcium Chloride

Calcium chloride will precipitate when used in conjunction with sodium bicarbonate. Toxicity with digitalis. May antagonize the effects of calcium channel blockers

32

Activated Charcoal

Do not administer at the same time as syrup of ipecac Ipecac will nullify the effects of activated charcoal

33

Morphine Sulfate

Enhanced CNS depression when administered with antihistamines, sedatives, barbiturates, and alcohol. Tricyclic antidepressants and MAOIs may precipitate hypotensive crisis

34

Fentanyl Citrate

Effects may be increased with other CNS depressants such as alcohol, narcotics, and sedative/hypnotics.
MAOI use may cause hypotension

35

Ketorolac (toradol)

Potentiates medications that inhibit platelet aggregation

36

Acetaminophen (tylenol, APAP)

Increased chance of hepatotoxicity when taken chronically or with alcohol, rifampin, carbamazepine, or barbiturates

37

Ibuprofen (Advil, Motrin, Nuprin)

Reduces the effectiveness of loop diuretics and ACE-inhibitors Increases hemorrhage potential when given with aspirin

38

Procainamide (Pronestyl)

Use caution when patient is on an antihypertensive agent