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Flashcards in Intro to aa Deck (26):
1

Which two amino acids do not have a corresponding tranaminase?

T, K

2

What are the functions of transaminiases?

Tranform amino acids into their alpha-keto acids and back.

3

What is required for all transaminase reactions?

Vitamin B6 (PLP)

4

True or false, tranamination reactions are freely reversible

True

5

What is the precursor for alanine?

Pyruvate

6

Which reaction does ALT catalyze?

pyruvate to alanine (via E +aKG)

7

What is a major reason ALT is important?

It allows muscles to transport pryruvate as an alanine to the liver during fasting. Pyruvate can then be used in gluconeogenesis.

8

What is the enzyme AST used for?

To catalyze the reaction from OAA to D (via E/aKG)

9

How is asparagine made?

From aspartate via ATP + E and asparagine synthase

10

Where is AST primarily found?

liver, cardiac and skeletal muscles, kidneys

11

Where is ALT primarily found?

Liver --this is why it is diagnostic for liver damage.

12

What does secretin cause the release of?

HCO3

13

What does cholecystokinin cause the release of?

Digestive enzymes

14

Which enzymes are activated by entreopeptidase?

Chymotripsin
Elastase
Carboxypeptidase

15

What is the ratio of poly peptides to free amino acids after degradation by pancreatic proteases?

60/40

16

Hartnup disease is the result of what? What are the symptoms? How is it treated>

Cannot uptake large, neutral amino acids
Results in pellegra due to no niacin
Treatment with niacin and large protein diet.

17

Celiac disease is caused by an immune reaction to what part of gluten?

Alpha gliadin

18

The body has how much free amino acids in the free amino acid pool?

100 g

19

aKG and OAA are precursors to what amino acids?

PRENDQ

20

pyruvate and 3PG are precursors for which amino acids?

AS

21

Glutamate dehydroenase gets its amino group from where?

Free ammonium ion

22

Glutamine synthetase gets its amino group from where?

Free ammonium ion

23

ALT forms what from what

Alanine from Pyruvate

24

Where does N get its amine from?

Q

25

Homocysteine uria is a problem with what enzyme? Symptoms? Treatment?

Cystathione beta-synthase.
Lens dislocation, osteoporosis, MR, thromboembolism
Low M, high S diet,

26

PKU is a problem with which two enzymes? Symptoms?

Either F-hydrolase or DHBtn reductase
MR, SZs, hypopigmentation