Intro to Metabolism 1 Flashcards

1
Q

Metabolism

A

total of all chemical reactions occurring in cell

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2
Q

Catabolism

A

reactions that release usable energy (ATP)

breakdown complex, ordered molecules into simple, disordered molecules

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3
Q

Anabolism

A

reactions that require energy;

build complex, ordered molecules from simple disordered molecules

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4
Q

Compare anabolism to catabolism

A

They do the opposite things

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5
Q

Energy

A

Energy = capacity to do work

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6
Q

3 types of work

A

chemical
transport
mechanical

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7
Q

Chemical work

A

Requires energy to synthesize complex biological molecules from simpler precursors

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8
Q

Transport work

A

Requires energy to take up nutrients,
eliminate wastes
maintain ion balances

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9
Q

mechanical work

A

Requires energy for cell motility and the movement of structures within cells
(i.e., partitioning of chromosomes during cell division)

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10
Q

Thermodynamics

A

analyzes energy changes in a collection of matter (i.e., a cell or a plant) called a system
Focuses on energy differences between initial state and final state of a system

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11
Q

How many laws of thermodynamics

A

2

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12
Q

First law of thermodynamics

A

Energy can be neither created nor destroyed, but can be converted from one form to another

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13
Q

Second law of thermodynamics

A

Physical and chemical processes proceed in such a way that the randomness or disorder of the universe (the system and its surroundings) increases

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14
Q

How is the second law measured

A

entropy

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15
Q

what is entropy

A

measure of the randomness or disorder of a system

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16
Q

Free Energy Change

A

How much energy is available to do work?

17
Q

How is free energy calculated? (G)

A

^G = ^H – T^S ^= change in

18
Q

What is ^H stand for in free energy calculation

A

change in enthalpy (bond energy; heat energy)

Absorb heat = +^H vs. Release heat = -^H

19
Q

What does T stand for in free energy calculation

A

T = “temperature in Kelvin (K)” (K = degree C + 273)

20
Q

What does S stand for in free energy calculation

A

change in entropy (disorder)

21
Q

If S is increasing

A

Increasing (requires input of E for less entropy (more ordered))

22
Q

what is ^Go’

A
the standard free energy change
Standard conditions (298K, 1 atm (pressure), at pH 7.0 (i.e., most living cells))
23
Q

what if ^Go’ is positive

A
exergonic reaction (proceeds spontaneously)
Provides energy to cell (with appropriate enzyme & pathway(s))
24
Q

what if ^Go’ is negative

A
endergonic reaction (does not proceed spontaneously)
Requires input of energy (with appropriate enzyme & pathway(s) to proceed)
25
Q

What is free energy G measured in

A

Joule (J) = energy unit; 1000 J = 1kJ (kilojoule)

26
Q

List of electron carriers

A

NAD+ (ox), NADH (red)
FAD (ox), FADH2 (red)
NADP+ (ox), NADPH (red)

27
Q

List of oxidation electron carriers

they get reduced (add a H)

A

NAD+, FAD, NADP

28
Q

List of Reduction electron carriers

they get oxidized (take off H and e)

A

NADH
FADH2
NADPH

29
Q

What do you notice with redox electron carriers

A

End with Hyrdogen

30
Q

A reduction reaction is one in

A

which a reactant in a chemical reaction gains one or more electrons (-).
So loses H+
higher energy

31
Q

A reduction reaction is one in

A

which a reactant in a chemical reaction gains one or more electrons (-).
So loses H+, Lose oxygen

higher energy

32
Q

An oxidation reaction is one in

see slide 7

A

an electron is removed (-)
so gains H+, Gain oxygen
lower energy
Dehydrogenation

33
Q

Does molecule have more or less energy when it gains electrons

A

MORE

34
Q

Oxidation-reduction reactions

LEO-GER; OIL-RIG

A

Leo= losing electrons oxidation
GER gaining electrons reduction
Oxidation is loss
reduction is gain

35
Q

Strongest reductants

see slide 10

A

More negative E0’ = donate e-

36
Q

electron tower

slide 10

A

e- “fall” down tower. Further e- “fall”, more energy released

37
Q

electron tower postive

slide 10

A
More positive E0' = accept e-
Strongest oxidants (accept e-)