Intro To Micro Antibiotic Pharmacology Flashcards Preview

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Flashcards in Intro To Micro Antibiotic Pharmacology Deck (24)
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1

What are Gram Positive organisms

Large peptidoglycan component of cell wall. this allows them to maintain and absorb crystal violet stain

2

Colonization of Normal flora

Just means they live with us, changes over time and we gain more and more diverse flora

3

Why do you want narrow as opposed to broad

Narrow specifically targets the pathogen while broad will kill all the flora which can lead to antibiotic resistance

4

How does antimicrobial usually get into pathogen for gram neg

Using porin proteins in the cell wall

5

How many organisms cause diseases at a time

typically only one but there are cases of more than one

6

What is typically used in treating bacteria

antibiotic, only treats bacteria

7

Flouoroquinolones antibiotics

Are DNA inhibitors and bind at DNA gyrase or topoisomerase IV
Ciprofloxacin, levofloxacin

8

Antimicrobial

Antibiotic that treats any kind of bacteria or virus or funcus

9

How does antimicrobial usually enter a gram positive cell

passive diffusion thro cell wall

10

Common Macrolides and Tetracycline antibiotics

Azthroymcyin, clorthromycin (macrolides)
Tetraycline, minocycline and doxycycline (terayline)

11

What are the requirements for antimicrobial activity

1. Reach site of infection
2. Penetrate cell
3.reach target and kill organism

12

What is the common bacterial morpholgies

Coccus (round), Bacillus (tube like/rod)

13

What are Gram Negative organism

Small peptidoglycan component in cell wall. Meaning alcohol decolonizes CV and must use safranin to stain it

14

What is treatment of infectious diseases depend on

1. Site of infection (does antibotic get to it)
2. the Pathogen (does the antibiotic treat it, is it narrow or broad spectrum)
3. patient factors (does pt have risk factors that make the pathogen resistant)
4. Route of administration (oral or IV)
5. Cost (how much does it cost the pt

15

Most common gram negative

Enterobacteriacease Family (e. coli) Pseudomonas aerginosa, haemophilus influenzae (respiratory infections), moraxella catterhalis (respiratory infection)

16

How does a pathogen relate to an infection

directly related to the signs and symptoms, because its there out immune system responds

17

Bacteria

Single celled organisms, no true nucleus (prokaryotic), very diverse. Most not harmful,

18

what are the most common gram positive pathogens

Staphylococcus, Streptococcus, Enterococcus

19

What does Normal Flora due in terms of diseases

Does not cause signs/symptoms, just living there

20

Beta-Lactans (penicillins, cephalospotins, carbapenems, monbactams) how do they work

Cell Wall inhibitors:
Work at penicillin-binding proteins to disrupt cell wall

21

Gram Stain process

4 steps
1. Using crystal violet
Causes everything to be purple
2. Iodine
used to set everything in place, intensifies CV
3. Alcohol (decoloring step)
removes violet from G- bacteria
4. Safranin
colors G- to be red

22

Pathogen

Organism which is causing disease (infection)

23

Normal Flora

Have these all over and they coexist without causing harm

24

Macrolides and Tetraycline antiboitc classes

Protein Inhibitors
Bind at ribosomes to block protein production and stopping pathogen