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Week 65: Sepsis > Intro to Sepsis > Flashcards

Flashcards in Intro to Sepsis Deck (8)
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1

4 effects of the cytokine storm in sepsis

Systemic vasodilation
Reduced cardiac contractility
Widespread endothelial injury and activation
Systemic activation of clotting cascade (DIC)

2

2 underlying reasons why people die from sepsis

Cytokine storm
Secondary immune dysfunction

3

Sepsis syndrome definition

Suspected or proven infection, in associated with:
Tachycardia, tachypnea, hyper or hypothermia, and dysfunction of 1 or more organs
It is a dysregulated host response

4

qSOFA criteria

2/3 of:
Altered mental status
Fast RR (> 22)
Low BP (< 100)

5

Septic shock definition

Need vasopressors to maintain a MAP of 65 mmHg
AND
Serum lactate level greater than 2 mmol/L in the absence of hypovolemia

6

Initial management of sepsis and septic shock

Within 3 hours of time of presentation:
1. Measure lactate level
2. Obtain blood cultures prior to administration of abx
3. Administer broad spectrum abx (want within 1 hour)
4. Administer 30 ml/kg crystalloid for hypotension or lactate >4 mM

7

What type of solution do we use in sepsis?

Ringer's lactate (or any other balanced solution)
NOT normal saline

8

Source control

Get rid of the underlying infection!
Surgical intervention when needed
Aggressive supportive care in ICU
Want it within at least 6-12 hours with the least invasive route possible