Flashcards in introduction to anaemia Deck (77)
what is anaemia?
reduced total red cell mass
what is a surrogate marker of anaemia?
what level of Hb is considered anaemia in adult males?
what level of Hb is considered anaemia in Adult females?
where does red cell production take place?
in the bone marrow
measuring hemoglobin concentration using a spectrophotometric method involves ---------- the red cells to create Hb solution
Stabilise the Hb molecules ---------
Measure the optical density (OD) at ----------
what is Beer's law?
OD proportional to the concentration
wat is calculated against a known reference standard cyan-metHb concentration solution?
Hb concentration is calculated against known reference of?
standard cyan-metHb concentration solution
how to measure hematocrit?
it is a ratio/percentage of the whole blood that is red cells if the sample was left to settle
how do modern machines measure hematocrit?
by adding the calculated volume of the red cells it counts
in what situations are Hb/Hct not good markers of anaemia?
wat are the two pathophysiological classifications of anaemia?
increased loss or destruction of red cells
when there is decreased production what is the reticulocyte count?
low reticulocyte count because you are not producing enough cells
when there is increased loss or destruction of red cells the reticulocyte count is?
increased because you are producing more cells to compensate the loss
hypo proliferative problems?
reduced amount of erythropoiesis , amount of production is a problem
present but ineffective erythropoiesis
impaired cell division
what two states cause in increased loss or destruction of red cells?
what is the difference between bleeding and hemolysis?
in bleeding no bilirubin present
why is there bilirubin present in hemolysis?
increase of breakdown products
if MCV iss low (microcytic) consider problems with?
if MCV is hight (macrocyclic) consider problems with?
if MCV is normal consider problems with?
where is HB synthesized?
to make Hb you need?
Haem : porphyrin ring, Iron (Fe2+)
causes of microcytic anaemia?
commonest iron deficiency (low body iron)
what is the second commonest cause of microcytic anaemia?
thalassemia which is when there is a globin deficiency