Iron metabolism

Question 1

Iron is an important cofactor for what

Answer 1

oxygen transport and electron transport chain

Question 2

Main storage organ for iron

Answer 2

Liver

Question 3

Heme iron comes from what sources

Answer 3

Animal sources

Question 4

Which is better absorbed heme or non-heme iron

Answer 4

Heme iron

Question 5

What are the sources of non heme iron

Answer 5

Plants

Question 6

Iron is required most in who

Answer 6

Pregnant women

Question 7

Non heme iron is reduced by what

Answer 7

Duodenal cytochrome B

Question 8

Non-heme iron is imported through what to enter cell

Answer 8

DMT1

Question 9

Non-heme iron is stored in

Answer 9

ferritin

Question 10

One ferritin complex can store how much iron

Answer 10

about 4500

Question 11

Heme iron is transported across the membrane by what

Answer 11

Heme carrier protein

Question 12

Heme iron is stored in what within the cell

Answer 12

Ferritin

Question 13

How is iron secreted from the body

Answer 13

ITS NOT SECRETED only regulated by absorption

Question 14

What is the only known iron exporter from the cells

Answer 14

Ferroportin

Question 15

Once iron leaves the cell its oxidized by what

Answer 15

Hephaestin

Question 16

Iron is transported through the blood bound to what

Answer 16

Transferrin

Question 17

Negative regulator of iron transport

Answer 17

Hepcidin (negative regulator)

Question 18

What inhibits hepcidin

Answer 18

Erythroferrone (positive regulator)

Question 19

Hepcidin is influenced by what

Answer 19

Inflammation and infection

Question 20

Transferrin binds to what at a target tissue

Answer 20

Transferrin receptor

Question 21

Best tests for iron levels

Answer 21

Serum ferritin & Transferrin saturation

Question 22

Serum ferritin measures what

Answer 22

Iron storage status

Question 23

Serum ferritin can be elevated by what

Answer 23

Inflammation or infection

Question 24

When is it useful to measure the levels of soluble transferrin receptor

Answer 24

during inflammation

Question 25

Low iron levels stimulates what

Answer 25

IRPs to bind IRE to increase levels of TfR

Question 26

Hemochromatosis

Answer 26

Excessive absorption of iron from dietary sources

Question 27

Hemochromatosis is from what

Answer 27

mutations in hepcidin, ferroportin, transferrin receptor (all negative regulators)

Question 28

How to treat iron overload

Answer 28

Chelating agents and gastric lavage