*Ischaemic heart disease (2) - MI Flashcards Preview

Study Notes - Cardiology > *Ischaemic heart disease (2) - MI > Flashcards

Flashcards in *Ischaemic heart disease (2) - MI Deck (71)
Loading flashcards...
1

What are the 4 main progressive steps involved in atherogenesis?

Normal -> fatty streak -> atheromatous plaque -> atherosclerotic plaque

2

What is atherosclerosis?

A disease of the arteries characterized by the deposition of fatty material on their inner walls causing progressive narrowing and hardening

3

What is an atheroma?

A fatty deposit in the intima

4

Risk factors for coronary heart disease?

Gender
Age
Drug abuse
alcohol
Smoking
Stress
Hypertension
High cholesterol
Obesity
Family history

5

What is chronic stable angina?

Chest pain caused by demand led ischaemia due to fixed stenosis which occurs in a predictable manner

6

What is the immediate treatment of chest pain due to chronic stable angina?

Stop
Sit
Spray

7

What is an acute coronary syndrome in general?

Any acute presentation of coronary artery disease
Only a provisional diagnosis that covers a spectrum of conditions
Like stable angina it is caused by ischaemia caused by atherosclerosis

8

What conditions are classified as acute coronary syndromes?

Unstable angina
NSTEMI
STEMI

9

What are 2 older alternative names for a NSTEMI?

Non-Q wave
Sub-endocardial MI

10

What are 2 older alternative names for a STEMI?

Acute MI (not called this anymore)
Q wave MI

11

What are the 2 types of MI?

ST elevation MI
Non ST elevation MI

12

Does a fatty streak cause symptoms?

No - it is clinically silent

13

What is the pathogenesis surrounding unstable coronary syndrome?

Plaque rupture/ fissure and thrombosis

14

What can happen to the plaque which bridges between an atherosclerotic plaque and plaque rupture/ fissure and thrombosis?

Fibrous cap forms over the fatty core

15

What type of stenosis does acute coronary syndrome have?
Type of ischaemia?

Dynamic stenosis (subtotal or complete occlusion)
Supply led ischaemia

16

What are the stages of the platelet cascade?

Initiation
Adhesion
Activation

17

What causes initiation of the platelet cascade?

Spontaneous plaque rupture which leads to exposed tissue elements (sub endothelial collagen and Von Willebrand factor)

18

What are factors affecting plaque rupture/ fissure? (6)

Lipid content of plaque
Thickness of fibrous cap
Sudden changes in intraluminal pressure or tone
Bending and twisting of an artery during each heart contraction
Plaque shape
Mechanical injury

19

What is von willebrand factor?

A glycoprotein that plays an important role in stopping the escape of blood from vessels

20

What is involved in adhesion (platelet cascade)?

Platelet recruitment and adhesion at the site of injury forming a monolayer

21

What is involved in activation (platelet cascade)?

Activators are released (ADP and Thromboxane A2)
They bind to surface receptors on platelets
Platelet activation accelerates resulting in platelet aggregation
Activated platelets express adhesion receptors for leukocytes (P-selectin and CD40 ligand) = inflammation
Organised fibrin-rich thrombus forms
(This leads to vascular blockage = acute MI/ stroke)

22

How is ADP and other activators released during platelet cascade?

Through degranulation

23

How is thromboxane A2 generated?

Via cycloxygenase

24

What adhesion receptors for leukocytes do activated platelets express (2)?

P-selectin
CD40 ligand

25

Difference between unstable angina and NSTEMI?

There is no elevation in cardiac enzymes in unstable angina where as there will be an elevation in cardiac enzymes in an NSTEMI (infarction does not occur- pre-MI which can lead to an MI)

26

Difference between a STEMI and NSTEMI?

There is only partial damage in heart muscle with an NSTEMI compared to full thickness damage to heart muscle with a STEMI - due to this full thickness damage ST elevation occurs on the ECG

27

What are ECG changes that are seen with a STEMI?

ST elevation
T wave inversion
Pathological Q waves

28

What must be present on an ECG to confirm a STEMI? (either one of 3 of)

Greater than or equal to 1mm ST elevation in 2 adjacent limb leads
Greater than or equal to 2mm elevation in at least 2 adjacent precordial leads
New onset bundle branch block (usually left bundle branch block)

29

What changes in Q waves indicate a problem?

> 40 ms (1 mm) wide
> 2 mm deep
> 25% of depth of QRS complex
-Seen in leads V1-3

30

What changes in ECG are seen in the first few hours of a STEMI?

ST elevation