jan 8 2021 Flashcards Preview

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Flashcards in jan 8 2021 Deck (20)
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1
Q

pathogenesis of immune thrombocytopenic purpura?

A

antibodies form against platelet membrane proteins leading to isolated thrombocytopenia

2
Q

first line treatment of immune thrombocytopenic purpura?

A

steroids and IV immunoglobulin

3
Q

second line treatment for ITP

A

splenectomy (removes the source of platelets destruction)

4
Q

what is chronic ITP ?

A

thrombocytopenia <100 000 and for > 1 year

5
Q

presentation of multiple system atrophy?

A
  • parkinsonism
  • autonomic dysfunction
  • widespread neurological signs
6
Q

what is familial-dysautonomia?

A

a AR disease that presents at birth with poor feeding, low muscle tone, gross autonomic dysfunction and severe orthostatic hypotension

7
Q

In a patient that presents with parkinsonism, and with orthostatic hypotension, erectile dysfunction, incontinence or other autonomic symptoms, consider….

A

multiple system atrophy

8
Q

cardiac amyloidosis causes…

A

restrictive cardiomyopathy

9
Q

list manifestations of amyloidosis

A
  • asymptomatic proteinuria or nephrotic syndrome
  • waxy skin
  • easy brusing
  • hepatomegaly
  • GI bleeding
  • early satiety
  • enlarged tongue
  • autonomic neuropathy
10
Q

presentation of HSV retinitis

A

rapidbly progressing bilateral necrotizing retinitis - starts with conjunctivitis and keratitis and eye pain followed by rapid progression of vision loss

11
Q

is it normal for breast bud development to occur unilaterally at first?

A

yes

12
Q

examination of a breast bud will show..

A

a firm retroareolar mass that may be slightly tender

13
Q

path of primary biliary cholangitis?

A

autoimmune destruction of intrahepatic bile ducts

14
Q

clinical features of primary biliary cholangitis?

A
  • fatigue/pruritis with progressive jaundice, hepatomegaly and cirhosis, xanthomas and xanthelasmas
  • usually in middle aged women
15
Q

which antibody is postivie in primary biliary cholangitis?

A

AMA (antimitochondrial)

16
Q

treatment of primary biliary cholangitis?

A
  • ursodeoxycholic acid

- liver transplant

17
Q

complications of primary biliary cholangitis?

A
  • malabsoprtion, fat soluble vitamin deficiencies
  • bone disease (osteoporosis, osteomalacia)
  • HCC
18
Q

which medications are risk factors for idiopathic intracranial hypertension?

A
  • retinoids
  • tetracylines
  • growth hormonep
19
Q

prolonged oxygen in a neonate is a risk for…

A

bronchopulmonary dysplasia

20
Q

characteristics of bronchopulmonary dysplasia?

A

reduced number and septations of alveoli