January 22, 2016 - Approach to ILD Flashcards Preview

COURSE 3 > January 22, 2016 - Approach to ILD > Flashcards

Flashcards in January 22, 2016 - Approach to ILD Deck (11):
1

Type I Pneumocyte

Flattened region of gaseous transport/diffusion, susceptible to injury.

2

Type II Pneumocyte

Site of surfactant production.

Can proliferate and reform alveolar epithelial surfaces.

3

What are Interstitial Lung Diseases?

More than 200 distinct diseases arising from the inflammation and/or fibrosis of the pulmonary interstitium.

Includes most of pulmonary medicine that isn't airways (asthma/COPD), infections, pleural disease.

4

Common Clinical Presentations for ILD

Cough

Dyspnea

Abnormal imaging

Hypoxemia

5

Approach to ILDs

Known causes (environmental/occupational, drugs/radiation)

Idiopathic interstitial pneumonias (most common is IPF)

Sarcoid

Lots of others

6

Idiopathic Interstitial Pneumonias

A subset of interstitial lung dieases.

The most common of this category by far is idiopathic pulmonary fibrosis (IPF).

7

Idiopathic Pulmonary Fibrosis (IPF)

Is a chronic and ultimately fatal disease characterized by a progressive decline in lung function.

Treatment is with pirfenidone and nintedanib.

8

Approach to Environmental/Occupational Exposures

Inorganic - silicosis, asbestosis, diametomaceous earth, aluminum oxide, berylliosis, etc.

Pneumoconioses - hard metal, coal workers, wood burning, etc.

Organic - bird fanciers, farmers, duck fever, sauna takers, coffee workers

9

Common Drugs and ILD

Nitrofurantoin - an antibiotic used to treat bladder infections

Methotrexate - anti-metabolite

Amiodarone - class III antiarrythmic drug

Bleomycin - used in cancer treatment

Radiation

10

Physical Exam Findings - ILD

Hands - cyanosis and clubbing

Chest - velcro crackles, inspiratory squeaks, expiratory wheeze

CVS - signs of pulmonary hypertension, right ventricular failure

11

Honeycombing

Is a radiological appearance seen with widespread fibrosis and is defined by the presence of small cystic spaces with irregularly thickened walls composed of fibrous tissue.

A image thumb

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