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Flashcards in Kapitel 6 Deck (34)
1

Enzyme that attaches the correct amino acid to a tRNA molecule to form an aminoacyl-tRNA. (Figure 6–54)

aminoacyl-tRNA synthetase

2

Sequence of three nucleotides in a transfer RNA (tRNA) molecule that is complementary to a three-nucleotide codon in a messenger RNA (mRNA) molecule.

anticodon

3

Sequence of three nucleotides in a DNA or mRNA molecule that represents the instruction for incorporation of a specific amino acid into a growing polypeptide chain.

codon

4

A summary or “average” of a large number of individual nucleotide sequences derived by comparing many sequences with the same basic function and tallying up the most common nucleotides found at each position. (Figure 6–12)

consensus nucleotide sequence

5

Average or most typical form of a sequence that is reproduced with minor variations in a group of related DNA - RNA - or protein sequences. Indicates the nucleotide or amino acid most often found at each position. Preservation of a sequence implies that it is functionally important.

consensus sequence

6

A conformation with loops or coils that DNA adopts in response to superhelical tension; conversely - creating various loops or coils in the helix can create such tension.

DNA supercoiling

7

Protein that helps load initiator tRNA on to the ribosome - thus initiating translation.

eukaryotic initiation factor (eIF)

8

Large protein complex with an interior rich in 3′-to-5′ RNA exonucleases; degrades RNA molecules to produce ribonucleotides.

exosome

9

Any of the proteins whose assembly at all promoters of a given type is required for the binding and activation of RNA polymerase and the initiation of transcription. (Table 6–3 - p. 311)

general transcription factor

10

The set of rules specifying the correspondence between nucleotide triplets (codons) in DNA or RNA and amino acids in proteins. (Figure 6–48)

genetic code

11

A principle for increasing the specificity of substrate recognition by proteins and RNAs. In protein synthesis - a ribosome - or enzyme folds around a codon–anticodon interaction and only when the match is correct is the subsequent reaction allowed to proceed.

induced fit

12

Special tRNA that intiates translation. It always carries the amino acid methionine - forming the complex Met-tRNAi. (Figure 6–70)

initiator tRNA

13

A principle for increasing the specificity of catalysis. In the synthesis of DNA - RNA - and proteins - it refers to a time delay that begins with an irreversible step (such as ATP or GTP hydrolysis) and during which incorrect base pairs are more likely to dissociate than correct pairs.

kinetic proofreading

14

RNA molecule that specifies the amino acid sequence of a protein. Produced in eukaryotes by processing of an RNA molecule made by RNA polymerase. It is translated into protein in a process catalyzed by ribosomes.

messenger RNA (mRNA)

15

Protein that helps guide the proper folding of other proteins - or helps them avoid misfolding. Includes heat-shock proteins (hsp).

molecular chaperone (chaperone)

16

An RNA molecule that is the final product of a gene and does not code for protein. These RNAs serve as enzymatic - structural - and regulatory components for a wide variety of processes in the cell.

noncoding RNA

17

Mechanism for degrading aberrant mRNAs containing in-frame internal stop codons before they can be translated into protein. (Figure 6–76)

nonsense-mediated mRNA decay

18

Large multiprotein structure forming an aqueous channel (the nuclear pore) through the nuclear envelope that allows selected molecules to move between nucleus and cytoplasm. (Figure 12–8)

nuclear pore complex (NPC)

19

Nucleotide sequence in DNA to which RNA polymerase binds to begin transcription. (Figure 7–44)

promoter

20

Nucleotide sequence in DNA to which RNA polymerase binds to begin transcription. (Figure 7–17)

promoter

21

Large protein complex in the cytosol with proteolytic activity that is responsible for degrading proteins that have been marked for destruction by ubiquitylation or by some other means. (Figures 6–83 and 6–84)

proteasome

22

The phase in which nucleotides are read in sets of three to encode a protein. An mRNA molecule can be read in any one of three reading frames - only one of which will give the required protein. (Figure 6–49)

reading frame

23

Any one of a number of specific RNA molecules that form part of the structure of a ribosome and participate in the synthesis of proteins. Often distinguished by their sedimentation coefficient (e.g. - 28S rRNA - 5S rRNA).

ribosomal RNA (rRNA)

24

Particle composed of rRNAs and ribosomal proteins that catalyzes the synthesis of protein using information provided by mRNA. (Figure 6–64)

ribosome

25

Enzyme that catalyzes the synthesis of an RNA molecule on a DNA template from ribonucleoside triphosphate precursors. (Figure 6–9)

RNA polymerase

26

Process in which intron sequences are excised from RNA transcripts. A major process in the nucleus of eukaryotic cells leading to formation of messenger RNAs (mRNAs).

RNA splicing

27

Hypothesis that early life on Earth was based primarily on RNA molecules that both stored genetic information and catalyzed biochemical reactions.

RNA world

28

Gene that specifies a ribosomal RNA (rRNA).

rRNA gene

29

Small RNA molecules that are complexed with proteins to form the ribonucleoprotein particles (snRNPs) involved in RNA splicing. (Figures 6–28 and 6–29)

small nuclear RNA (snRNA)

30

Small RNAs found in the nucleolus - with various functions - including guiding the modifications of precursor rRNA. (Table 6–1 - p. 305 - and Figure 6–41)

small nucleolar RNA (snoRNA)

31

Large assembly of RNA and protein molecules that performs pre-mRNA splicing in eukaryotic cells.

spliceosome

32

Sequence in the promoter region of many eukaryotic genes that binds a general transcription factor (TFIID) and hence specifies the position at which transcription is initiated. (Figure 6–14)

TATA box

33

Signal in bacterial DNA that halts transcription; in eukaryotes - transcription terminates after cleavage and polyadenylation of the newly synthesized RNA.

terminator

34

Set of small RNA molecules used in protein synthesis as an interface (adaptor) between mRNA and amino acids. Each type of tRNA molecule is covalently linked to a particular amino acid. (Figure 6–50)

transfer RNA (tRNA)