Kidney Flashcards

(64 cards)

1
Q

What are Crescents made of?

A

Prolifaration of parietal cells and infiltration of WBCs

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2
Q

Types of Rapidly Progressive (Crescentic) Glomerulonephritis

A

Type I anti-GBM (Goodpasture)

Type II Immune Complex (Post-infection GN)

Type III Pauci-immune ANCA (Wegener)

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3
Q

Pattern in Goodpasture

A

Linear

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4
Q

Pattern in Type II Immune Complex

A

Granular

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5
Q

What does Nephrotic Syndrome present with?

A

Proteinuria > 3.5 & Hypoalbuminemia

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6
Q

Common cause of Nephrotic syndrome in Caucasian Adults

A

Membranous Nephropathy

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7
Q

Thickening of the glomerular capillary wall

A

Membranous Nephropathy

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8
Q

Pattern of Membranous Nephropathy is

A

Granular, Subepithelial

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9
Q

Common cause of Nephrotic syndrome in Children

A

Minimal Change Disease

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10
Q

Effacement of foot process and NO immune complex is

A

Minimal Change Disease

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11
Q

Common cause of Nephrotic syndrome in Hispanic and African Adults

A

Focal Segmental Glomerulosclerosis

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12
Q

Loss of foot process and Epithelial damage is

A

Focal Segmental Glomerulosclerosis

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13
Q

Associated with HIV

A

Focal Segmental Glomerulosclerosis

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14
Q

Associated with HBV, HCV, and SLE

A

Membranous Nephropathy

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15
Q

Type I Membranoproliferative Glomerulonephritis is

A

Immune complexes resulting in Subendothelial deposites

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16
Q

Type II Membranoproliferative Glomerulonephritis

A

Alternative Complement Pathway (C3)

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17
Q

Berger Disease is

A

IgA Nephropathy

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18
Q

What do you see in IgA Nephropathy?

A

Henoch-Schonlein Purpura

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19
Q

What is IgA Nephropathy associated with?

A

Gluten Enteropathy

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20
Q

Two types of Hereditary Nephritis

A

Aplort Syndrome

benign Famelial hematuria

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21
Q

Alport Syndrome presents with

A

Nephritis
Chronic Renal Failure
Nerve Deafness
Eye Disorders

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22
Q

Alport Syndrome is an abnormality of a chains in

A

Type IV Collagen

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23
Q

List Types of SLE Nephritis

A
Type I - No renal Involvement
Type II - Mesangial Form 
Type III - Focal-Proliferative
Type IV - Difuse-Proliferative (Most Severe; Crescentic)
Type V - Membranous (thickening of GBM)
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24
Q

Purpuric skin lesions characteristically involving extensor surfaces of arms/legs as well as butt

A

Henoch-Scholein Purpura (deposition of IgA)

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25
Nodular Glomerulosclerosis (or Kimmelsteil-Wilson Disease) is associated with
Diabetic Glomerulonephritis
26
Nonenzymic glycosylation of the GBM (increasing permeability and thickness)
Diabetic Glomerulonephritis
27
Inheritance of Alport Syndrome
X-linked
28
Most common cause of Acute Renal Failure
Acute Kidney Injury (or Acute Tubular Necrosis)
29
Most commence sue of Pyelonephritis and UTI
E. coli
30
Halmarks of Acute Pyelonephritis
Patchy Interstitual Suppurative Inflammation | & Intratubular Aggregates, Tubular Necrosis
31
Three complications of Acute Pyelonephritis
Papillary Necrosis (in diabetics) Pyonephrosis Perinephric Abscess
32
What do you see in Chronic Pyelonephritis?
WBC Casts
33
What is Chronic Pyelonephritis usually associated with?
Vesicocurethral or Intrarenal Reflux
34
Acute Drug-Induced Interstitial Nephritis most commonly caused by
Penicillins
35
Analgesic Nephropaty is caused by excessive intake of analgesic mixtures of
Phenacetin and Aspirin, Caffeine, Acetaminophen, Codeine
36
Acute Uric Acid Nephropathy occurs where and why?
In collecting Ducts because favor Acidic pH
37
Chronic Urate Nephropathy is a result of
MUS, also called Gouty Nephropathy
38
Nephrolithiasis is
Uric acid stones
39
Bence Jones Casts
Myeloma Kidney (Light-chain Cast Nephropathy)
40
What do you see in Benign Nephrosclerosis?
Hyalin Arteriosclerosis
41
What do you see in Malignant Hypertension?
Onion Skinning
42
Typical HUS is caused by
Shiga-like Toxins from E. coli (O157:H7)
43
TTP is caused by
ADAMTS13
44
Because of "End Organ" nature of blood supply, most renal infarcts are
"White" Anemic Infacts
45
Adult Polycystic Kidney Disease is inherited
Autosomal Dominant
46
Childhood Polycystic Kidney Disease is inherited
Autosomal Recessive
47
AD (or Adult) Polycystic Kidney Disease is associated with
Berry Aneurysms and Mitral Valve Polapse
48
AR (or Childhood) Polycystic Kidney Disease is associated with
Hepatic Fibrosis
49
40% AD (or Adult) Polycystic Kidney Disease die of
Coronary or Hypertensive Heart Disease
50
Dilation of renal pelvis and calyces with atrophy of kidney from obstruction to the outflow of urine
Hydronephrosis (from UT Obstruction)
51
What is the term for renal stones?
Urolithiasis
52
The majority of renal stones are
Calcium Stones (70%)
53
What are Triple Stones made of?
Magnesium, Ammonium, and Phosphate
54
Stones that have Staghorn Cells are
Triple Stones
55
Four types of Kidney Stones are
Calcium, Triple, Uric Acid, and Cysteine
56
Kidney Stones are favored in
Renal Calyces/Pelvis or Bladder
57
Most common malignant tumor of the Kidneys is
Renal Cell Carcinoma (Adenocarcinoma)
58
What is the most significant risk factor of Renal Cell Carcinoma (Adenocarcinoma)?
Tobacco
59
Most common form of Renal Cell Carcinoma (Adenocarcinoma) is
Clear Cell (70-80%)
60
A form of Hereditery Renal Cell Carcinoma (Adenocarcinoma) is
Von Hippel Lindau (VHL gene)
61
Papillary Carcinoma results from
Trisomy 7 & MET Gene
62
Clear Cell Carcinoma results from
Sporadic: VHL Hereditary: Chromosome 3
63
Three classic diagnostic features of Renal Cell Carcinoma (Adenocarcinoma)
CVA pain, palpable mass, hematuria
64
Most common metastasis of Renal Cell Carcinoma (Adenocarcinoma) is
Lungs (50%); Usually metastasize before giving rise to any local symptoms or signs