Kleyn - Appendix 1 Flashcards
(29 cards)
What are the NRTIs?
-Abacavir
-Emtricitabine
-Lamivudine
-Tenofovir disoproxil fumarate
-Tenofovir alafenamide
-Zidovudine
What nucleoside is abacavir an analog of?
Guanine
What nucleoside is emtricitabine an analog of?
Cytosine
What nucleoside is lamivudine an analog of?
Cytosine
What nucleoside is tenofovir an analog of?
Adenosine
What nucleoside is zidovudine an analog of?
Thymidine
Abacavir adverse effects
Hypersensitivity reactions
What tests must be done before giving abacavir?
HLAB5701 test
Tenofovir disoproxil fumarate adverse effects
-Renal insufficiency
-Osteomalacia
Zidovudine adverse effects
Bone marrow suppression
What are the NNRTIs
-Efavirenz
-Nevirapine
-Etravirine
-Rilpivirine
-Doravirine
Efavirenz clinical pearls
-Take on an empty stomach at bedtime
-Can cause CNS issues such as somnolence, abnormal dreams, suicidal thoughts
Nevirapine clinical pearls
Titrate dose over 14 days to prevent stevens-johnson syndrome
Etravirine clinical pearls
Must take with food
Rilpivirine clinical pearls
Must take with fatty food
What are the protease inhibitors
-Atazanavir
-Darunavir
-Fosamprenavir
-Lopinavir/ritonavir
-Nelfinavir
-Ritonavir
-Tipranavir
Atazanavir clinical pearls
-Take with food
-Can cause indirect hyperbilirubinemia
Ritonavir clinical pearls
-Nausea
-Vomiting
-Diarrhea
Cobicistat clinical pearls
Can cause an increase in serum creatinine that has no correlation with glomerular filtration rate
What are the INSTIs?
-Raltegravir
-Elvitegravir
-Dolutegravir
-Bictegravir
-Cabotegravir
Raltegravir clinical pearls
CK elevations
Elvitegravir clinical pearls
Take with food
Dolutegravir dosing
-50 mg daily for INSTI naive patients
-50 mg BID for patients who have taken an INSTI before or when co-administered with UGT1A/CYP3A4 inducers
Which drugs are in Biktarvy?
-Bictegravir
-Emtricitabine
-Tenofovir
