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Flashcards in KNOW THIS Deck (121)
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1

S/E of b-agonists

Hypokalemia

2

IF: granular pattern of immune complex deposition; LM: diffuse capillary thickening

membranous GN or Diffuse Proliferative GN

3

IF: granular pattern of IC deposition; LM: hyper cellular glomeruli

Acute PSGN

4

IF: deposition of IgG, IgM, IgA, C3 in the mesangium

Acute PSGN

5

EM: sub endothelial humps and "tram-track" appearance

Membranoproliferative GN

6

Crescent formation in glomeruli

RPGN

7

LM: segmental sclerosis & hyalinosis

Focal Segmental glomerulosclerosis

8

EM: spiking if the GBM d/t electron-dense sub epithelial deposits

Membranous GN

9

Heparin MOA

enhances Anti-thrombin III activity, blocking thrombin

10

Thrombolytics MOA

activate plasmin to degrade fibrin

11

Warfarin MOA

inhibit epoxide reductase (recycles Vit k)

12

Absence of HGPRTase

Lesch-Nyhan

13

Aldolase B deficiency

Fructose intolerance

14

Cystathionine Synthase deficiency

Homocysteinuria

15

Galactose-1-phosphate UDT deficiency

Galactosemia

16

MR, HSM, cataracts

Galactosemia

17

Tyrosinase deficiency

Albinism

18

Burr cells/Echinocytes are seen w/

kidney disease (uremia) (regular spiking of RBC)

19

Acanthocytes/Spur cells are seen w/

abetalipoproteinemia, Liver ds (irregular RBC spiking)

20

Deficiency of spectrin or ankyrin

Hereditary spherocytosis

21

Target cells are seen w/

"THAL" Thalassemia, HbC, Asplenia, Liver Ds

22

Sideroblasts are seen w/

sideroblastic anemia (iron in mito)

23

"spike and dome" appearance

Membranous GN

24

"Tram-track" appliance of sub endothelial humps

Membranoproliferative GN

25

rate-limiting enzyme of heme synthesis

ALA synthase (glycine + succinyl-CoA -> delta-ALA)

26

Acute Intermittent Porphyria Sx

abd pain, red urine, polyneuropathy, psych disturbances

27

Acute Intermittent Porphyria - enzyme deficiency?

porphobilinogen

28

Acute Intermittent Porphyria - Tx

Heme & glucose (negative feedback to ALA synthase)

29

Porphyria Cutanea Tarda - Sx

blistering of skin, photosensitive, tea-colored urine, hypertrichosis, facial hyperpigmentation

30

Porphyria Cutanea Tarda - enzyme deficiency

Uroporphyrinogen decarboxylase