Flashcards in KNOW THIS Deck (121)
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1
S/E of b-agonists
Hypokalemia
2
IF: granular pattern of immune complex deposition; LM: diffuse capillary thickening
membranous GN or Diffuse Proliferative GN
3
IF: granular pattern of IC deposition; LM: hyper cellular glomeruli
Acute PSGN
4
IF: deposition of IgG, IgM, IgA, C3 in the mesangium
Acute PSGN
5
EM: sub endothelial humps and "tram-track" appearance
Membranoproliferative GN
6
Crescent formation in glomeruli
RPGN
7
LM: segmental sclerosis & hyalinosis
Focal Segmental glomerulosclerosis
8
EM: spiking if the GBM d/t electron-dense sub epithelial deposits
Membranous GN
9
Heparin MOA
enhances Anti-thrombin III activity, blocking thrombin
10
Thrombolytics MOA
activate plasmin to degrade fibrin
11
Warfarin MOA
inhibit epoxide reductase (recycles Vit k)
12
Absence of HGPRTase
Lesch-Nyhan
13
Aldolase B deficiency
Fructose intolerance
14
Cystathionine Synthase deficiency
Homocysteinuria
15
Galactose-1-phosphate UDT deficiency
Galactosemia
16
MR, HSM, cataracts
Galactosemia
17
Tyrosinase deficiency
Albinism
18
Burr cells/Echinocytes are seen w/
kidney disease (uremia) (regular spiking of RBC)
19
Acanthocytes/Spur cells are seen w/
abetalipoproteinemia, Liver ds (irregular RBC spiking)
20
Deficiency of spectrin or ankyrin
Hereditary spherocytosis
21
Target cells are seen w/
"THAL" Thalassemia, HbC, Asplenia, Liver Ds
22
Sideroblasts are seen w/
sideroblastic anemia (iron in mito)
23
"spike and dome" appearance
Membranous GN
24
"Tram-track" appliance of sub endothelial humps
Membranoproliferative GN
25
rate-limiting enzyme of heme synthesis
ALA synthase (glycine + succinyl-CoA -> delta-ALA)
26
Acute Intermittent Porphyria Sx
abd pain, red urine, polyneuropathy, psych disturbances
27
Acute Intermittent Porphyria - enzyme deficiency?
porphobilinogen
28
Acute Intermittent Porphyria - Tx
Heme & glucose (negative feedback to ALA synthase)
29
Porphyria Cutanea Tarda - Sx
blistering of skin, photosensitive, tea-colored urine, hypertrichosis, facial hyperpigmentation
30
