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Flashcards in Pharmacology Deck (55):
1

Treatment for Syphilis

Penicillin G

2

Penicillin G & V Tx

G(+) - S. pneumo, S. agalactiae, S. pyogenes, Spirochetes, Actinomyces, Clostridium, Listeria, Bacillus, Neisseria

3

S/E of Penicillin

HSN, Hemolytic anemia, Thrombocytopenia

4

Penicillinase-Resistant Abx's?

Methicillin, Nafcillin, Oxacillin, Dicloxacillin

5

Penicillinase-Resistant Abx MOA

bulky R group blocks beta-lactamase from cleaving beta-lactam ring
Alteration of PCP site

6

Penicillinase-Resistant Abx S/E

HSN

7

Penicillinase-Resistant Abx Tx

S. aureus

8

MRSA resistance is acquired via

PCP alteration

9

Ampicillin & Amoxicillin provide coverage for what agents

G(+) + "HELPSS"
Haemophilus influenzae, Enterococci, Listeria, Proteus mirabilis, Salmonella, Shigella

10

Which is given orally & which IV, Ampicillin & Amoxicillin?

Amoxicillin (oral)
Ampicillin (IV)

11

Ampicillin & Amoxicillin S/E

HSN, Rash from mononucleosis

12

B-lactamase Inhibitors (3)

Clavulanic Acid, Sulbactam, Tazobactam

13

Anti-Pseudomonals (3)

Ticarcillin, Carbenicillin, Piperacillin

14

Most neonatal infections can be treated w/

Ampicillin (Listeria, E. coli coverage)

15

Tx for Acid Reflux w/ S/E of gynecomastia

Cimetidine

16

Ondansetron MOA

blocks 5-HT-3 receptors in periphery and centrally (vagal stimulation, area postrema and CRTZ)

17

Ondansetron Uses

anti-emetic for post-operative or chemo-induced emesis

18

5-FU is used mainly to Tx

Colon Cancer

19

5-FU S/E

pancytopenia (myelosuppression)

20

5-FU is most effective when given w/

Leucovorin

21

NSAID commonly given parenterally

Ketorolac

22

Flutamide MOA

anti-androgen receptor

23

Essential tremors (b/l UE tremor, worsen as intention tremor) is treated primarily w/

non-selective beta-blocker

24

Demeclocycline Uses

Tetracycline
SIADH (ADH receptor blocker)

25

Quinidine S/E

Torsades de Pointe (prolonged QT)
Cinchonism (HA, tinnitus, visual disturbance, etc)

26

Ketoconazole S/E

gynecomastia, decreased libido

27

Ketoconazole MOA

inhibition of ergosterol synthesis, amenorrhea

28

DES S/E

in female offspring --> T-shaped uterus, transverse vaginal septum, risk of clear cell adenocarcinoma

29

Finasteride MOA

5-alpha-reductase inhibitor

30

Finasteride Uses

BPH

31

Which NRTI causes anemia + reticulocytopenia

Zidovudine

32

Cisplatin S/E

Ototoxicity & Nephrotoxicity

33

Methacholine Use

Challenge test in the diagnosis of asthma

34

Misoprostol Use

Stimulate mucin & bicarbonate production in gastric cells

35

Acyclovir MOA

activated by phosphorylation by viral thymidine kinase --> inhibition of viral DNA synthesis by inhibiting DNA pol

36

Which drugs are used prior to surgical resection of pheochromocytoma?

alpha-1 & -2 blockers

37

Phenoxybenzamine

alpha-1 & -2 blockers used prior to pheochromocytoma resection

38

Olanzepine Drug Class

Atypical antipsychotic

39

Olanzepine S/E

weight gain, DM-II, glycosylated Hgb

40

Olanzepine MOA

partial DA antagonist & partial 5-HT antagonist

41

non-Sulfa Loop Diuretic

Ethacrynic Acid

42

Exenatide S/E

hypoglycemia & acute pancreatitis

43

Exenatide MOA

acts on GLP-1 pancreatic receptors to induce Insulin secretion

44

Exenatide Use

DM-II

45

Pioglitazone MOA

PPAR-gamma agonist -> increased tissue sensitivity to insulin

46

Pioglitazone S/E

edema, weight gain, CHF

47

Metformin MOA

decreases hepatic gluconeogenesis & increased tissue sensitivity to insulin

48

Metformin S/E

GI Sx, Lactic Acidosis (esp in pts w/ renal failure)

49

Vancomycin S/E

"NOT" Nephrotoxicity, Ototoxicity, Thrombophlebitis
"Red Man Syndrome" release of histamine

50

Gray Baby Syndrome

Chloramphenicol

51

Gray Man Syndrome

Amiodarone

52

Bromocriptine MOA

DA agonist

53

Metoclopramide MOA

DA antagonist

54

Metoclopramide S/E

hyperprolactinemia

55

Medications commonly associated w/ SJS?

NSAIDs
Allopurinol
Phenytoin, Carbamazepine, barbiturates, anticonvulsants
sulfa antibiotics