KREBS CYCLE Flashcards

(39 cards)

0
Q

It is the final common pathway bec all biomolecules can enter

A

Krebs cycle

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
1
Q

Other term for krebs cycle

A

Citric acid cycle

tricarboxylic acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Where krebs cycle is located

A

Mitochondrial matrix

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Three enzymes used to produce acetyl coA

A

Pyruvate dehydrogenase complex

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

During glycolysis,glucose is converted into

A

PYRUVATE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Pyruvate undergoes removal of carboxyl grp

A

Oxidative decarboxylation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Coenzymes used to produce acetyl coA

A
NAD
FAD
CoA SH
NADH
Lipoate
TPP thymine pyro phosphate
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Formation of NADH and FADH2 is catalyzed by

A

Dihydrolipoyl dehydrogenase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

E1

A

Pyruvate dehydrogenase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

E2

A

Dihydrolipoyl transacetylase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

E3

A

Dihydrolipoyl dehydrogenase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Step 1:
Acetyl coA + _______ = Citrate
Enzyme used:

A

Oxaloacetate

Citrate synthase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Step 2: Citrate ➡️ Isocitrate

What enzyme?

A

Aconitase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

This step shows you
rearrangement of func group or isomerization
reversible

A

Step 2: formation of isocitrate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Step that shows generation of NADH

A

3 oxidation of isocitrate to a-KT & CO2
4 oxidation of a-KT to succinyl coA and CO2
8 oxidation of malate to oxaloacetate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Irreversible
NAD ➡️ NADH
NADP ➡️ NADPH

A
  1. Oxidation of a-KT & Co2
16
Q

Enzyme in step 3/ oxidation of a-KT & Co2

A

Isocitrate dehydrogenase

17
Q

Enzyme in formation of citrate

Step 1

A

Citrate synthase

18
Q

Enzyme in formation of isocitrate

Step 2

19
Q

Carries 3 mol

20
Q

Steps that shows:
Generation of NADH
Irreversible
Oxidation & decarboxylation

A

Step 3: oxidation of isocitrate to a-KT & Co2

Step 4: oxidation of a-KT to succinyl coA & Co2

21
Q

Enzyme in step 4/ oxidation of a-KT to succinyl coA & co2

A

A-ketoglutarate dehydrogenase complex

22
Q

High energy compound

Reactive product of the reaction

23
Q
Step 5:
Reactant:
Enzyme:
Product:
Production of....
A
Conversion of succinyl coA to succinate
Reactant: Succinyl coA 
Enzyme: succinyl coA synthetase or thiokinase
Product: succinate
GDP*
24
This step demonstrates SUBSTRATE LEVEL OF PHOSPHORYLATION
Step 5 | Conversion of succinyl coA to succinate
25
Charac of step 5-- | Forms atp/ gtp without entering electron transport chain
Substrate level of phosphorylation
26
Step 6: Enzyme: Formation of ___
Oxidation of succinate to fumarate Succinate DEhydrogenase FADH2
27
Step 7: | Enzyme:
Hydration of fumarate to malate | Enzyme: fumarase
28
Step 8: | Emzyme:
Oxidation of malate to oxaloacetate | Malate dehydrogenase
29
Products formed in krebs cycle
3 NADH GDP FADH2
30
of atp.. NADH GDP FADH2
N-3 F-2 G-1
31
How many atp based on 1 mol of acetyl coa
12 atp
32
Enzyme in substrate level of phosphorylation
Succinyl coA synthetase
33
Irreversible steps and enzymes..
1. Formation of citrate - citrate synthase 3. Oxidation of isocitrate to a-KT & co2 4. Oxidation of a- KT to succinate & co2 - a ketoglutarate dehydrogenase complex
34
Reversible reaction | Serves as replenishment for Krebs cycle
Anaplerotic reaction
35
Product formed in anaplerotic rxn
Oxaloacetate
36
Rate limiting enzymes that catalyze rate limiting steps
Citrate synthetase Isocitrate dehydrogenase A ketoglutarate dehydrogenase complex
37
step ➡️ FADH2
Step 6 | Oxidation of succinate to fumarate
38
Step ➡️ GDP
Step 5 | Conversion of succinyl coA to succinate