L22 - GIT cancers

Question 1

What is oesophageal cancer?

Answer 1

• cancer in the oesophagus
  -two types - SCC and ADC
  -

Question 2

What is ADC and what is its predispostion factor

Answer 2

• adenocarcinoma
• the factor is barret metaplasia where there is an excessive reflux of stomach acid into the oesphagus
• the straitified squqmous epithelium changes to columnar type epithelium

Question 3

What is SCC

Answer 3

squamous cell carcinoma

Question 4

risk factors of ADC

Answer 4

-gender, age, reflux, obesity

Question 5

what factors can decrease the risk of ADC

Answer 5

-h.PYLORI
-fruits and veg
anti oxidants

Question 6

what is the most important risk factor for gastric cancer

Answer 6

H.pylori

Question 7

What is caused when there is Hp infection in the antrum

Answer 7

• hypergastrinaemia ( produces lots of acid )

- duodenual ulcers (acid overwhelming the duodenum

Question 8

What is caused when there is Hp infection in the corpus

Answer 8

• reduced acid secretion (supression of parietal cells due to an immune response)
• hypocholorydria

Question 9

treatment for gastric cancer

Answer 9

AB of amoxicillin and clarithromycin

- proton pump inhibitor

Question 10

What is HDGC caused by

Answer 10

germline mutation in CDH1 gene so the cells aren’t bound together and becomes disorganised