L27 BW (HIV) Flashcards
(36 cards)
how long dose the development of AIDS lag behind HIV
a decade
NRTI MOA
competitive inhibitors that inhibit the production of DNA by premature chain termination
HIV ___ is more prevalent worldwide,
whereas HIV ___ is more prevalent in W. Africa
HIV 1 is more prevalent worldwide,
whereas HIV 2 is more prevalent in W. Africa
how is donated blood screened for HIV
(1) the presence of HIV antigens (p24) or (2) RNA NAT
what complicates tx and necessitates the use of combo chemo to suppress infections
the fast mutation rate
how do we break HIV transmission
education about U=U
undetectable = untransmissable
+ PrEP
AIDS defining conditions emerge when
as immune system fails due to opportunistic infections, CA and other conditions
U = U
Undetectable = Un-transmissible
reverse transcriptase inhibitors include
nucleoside/tide analogs and non-nucleoside reverse transcriptase inhibitors
why is simultaneous tx with multiple agents required in HIV
HIV has such a high mutation rate
what makes us hope that more HIV infections will be recognized sooner
that HIV antibody detecting rapid tests are in use
what population in the US is currently showing the greatest rates of increase
heterosexuals
what reduces emergence of opportunistic infections, threat from AIDS associated CA, and reduced risk of transmission
starting HAART early
what does the future of HIV tx?
maturation inhibitors and integrase inhibitors
How do you determine tx for HIV pts
watch viral loads trends. If they dip, adjust meds
downsides of the typical infection screening approach
does not ID pts with recent infections who have not yet developed an antibody response
best method of HIV prevention
education
combination of which 2 drug groups has made a huge difference in clinical condition of HIV pts and sinks the virus to undetectable levels
protease inhibitors
and
nucleotide analogs
is donated blood safe from HIV
yes- the 2 techniques it uses do not rely on patient antibodies (which can take a while to develop in an infected person)
HIV tx is ___ but ____
HIV tx is difficult but compliance is essential to avoid drug resistance
HIV virus load pattern
rise, dip, return
fusion penetration inhibitors
interfere with HIV entry into host
what test ID’s HIV even if the pt has not yet developed antibodies
Nucleic Acid Tests (NAT)
protease inhibitors
stop maturation/ viral assembly
