L3 - Passive membrane transport Flashcards
(22 cards)
Membrane protein function
Membrane transport
Receptors
Enzymes
Adhesion
Identity
Membrane transport
What goes in and out of cells
Receptors
communicate to other cells and tissues
Enzymes
Catalyse reactions
Adhesion
Adhesion molecules connect adjacent cells
Identity
Identitiy molecules give cells unique immune signature
Passive movement
Doesnt require energy
High conc to low conc
Flux
Rate at which passive movement occurs
What does flux depend on
steepness of conc gradient
area of interface
type of molecules (large mlecules diffuse slower)
thickness of diffusion distance
Simple diffusion
Small and non-polar substances e.g. O2, CO2
Steroid hormones, lipophilic drugs, water
Facilitated diffusion
Polar substances e.g. glucose, amino acids
Via carrier proteins
Doesnt require energy
Carrier protein (glucose)
- Raised blood glucose creates chemical force for influx
- Glucose binds to GLUT1 carrier, changes shape, and is released to the inside
Through ion channels
Ions move across membrane via water filled pores of ion channels
1. High extracellular Na+ creates chemical force for influx
2. Small aqueous pores allow Na+ to flow down conc gradient
Non-gated ion channels
Mostly open
Ligand-gated ion channels
Open in response to chemical stimuli
Mechanically gated ion channel
Open in response to mechanical stress applies to membrane
Voltage-gated ion channel
Open in response to changes in membrane potential
Osmotic diffusion
Water moving across membrane
Aquaporins allow for greater diffusion of water
Isotonic
Solution has same conc of solute as inside a cell
Hypotonic
Less conc of solute
Cell swells
Hypertonic
More conc of solution
Cells shrinks
Types of passive diffusion
- Simple
- Facilitated diffusion
- Through ion channels