L31. Drug Detoxification Pathways Flashcards Preview

04. Gastrointestinal > L31. Drug Detoxification Pathways > Flashcards

Flashcards in L31. Drug Detoxification Pathways Deck (32)
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31

How does dioxin (environmental pollutant) induce CYP 1A2?

Dioxin binds to hydrocarbon in the cytosol
This translocates to nucleus and binds to response elements and this upregulates expression of the cytochrome.
This is beneficial to removing the toxin but also upregulates the action.

32

What are some other endogenous functions of the CYPs?

1. metabolism of vascular autoregulation (esp in the brain)
2. formation of cholesterol, steroids and arachadonic acid metabolites