L35- Steroid Pharmacology (corticosteroid antagonists) Flashcards Preview

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Flashcards in L35- Steroid Pharmacology (corticosteroid antagonists) Deck (12)
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1

list the corticosteroid antagonists

Gluco: Mifepristone

Mineralo: Spironolactone

2

Spironolactone MOA

competes with aldosterone for renal receptors

3

Spironolactone uses

-aldosteronism (Dx, Tx)
-diuretic
-hirsutism in women --> androgen antagonist

4

Spironolactone AEs

-hyperkalemia
-cardiac arrhythmia

-menstrual abnormalities
-gynecomastia
-sedation
-HAs
-GI issues
-skin rashes

5

Mifepristone MOA

antagonist at glucocorticoid receptors and progesterone receptors

6

Mifepristone uses

inoperable ectopic ACTH syndrome or adrenal carcinoma

7

list the steroid synthesis inhibitors

-ketoconazole
-aminoglutethimide
-metyrapone

8

Aminoglutethimide:
-(1) MOA
-(2) uses

1- blocks cholesterol to pregnenolone --> reduces synthesis of all steroid hormones

2- adrenal cancer adjunct with hydrocortisone / dexamethasone

9

Ketoconazole:
-(1) MOA
-(2) uses

1- potent non-selective inhibitor of adrenal and gonadal steroid synthesis

2- Cushing's syndrome, Prostate cancer

10

Metyrapone MOA

selective inhibitor of steroid 11 hydroylation --> interferes with cortisol and corticosterone (--> aldosterone) synthesis

11

Metyrapone uses

tests adrenal function

Cushing's syndrome in pregnancy

12

Metyrapone AEs

-salt / water wasting
-hirsutism

-transient disease
-GI disturbances