L35- Steroid Pharmacology (cortisol + general) Flashcards Preview

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Flashcards in L35- Steroid Pharmacology (cortisol + general) Deck (12)
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1

list the hormonal steroids + main purpose

Glucocorticoids- effects intermediary metabolism and immune function

Mineralocorticoids- salt retaining activity

Steroids: androgenic, estrogenic

2

cortisone = ______ pharmacologically

hydrocortisone

3

_______ are the names for hydrocortisone receptors

(cortisol)
receptor in cytoplasm --> nucleus --> receptor hormone complex binds GRE(dna) = glucocorticoid response elements

4

list the catabolic effects of hydrocortisone

[1) protein --> AA release]
2) CT, muscle, lymphoid, peripheral fat and skin ==> wasting at high concentrations (thinning of skin)

long-term therapy limits:
3) osteoporosis
4) children- growth retardation

5

list the immunosuppressive effects of hydrocortisone

1) Leukocytes
-inc neutrophils: inc in blood, dec migration from BVs
-dec lymphocytes (T/B cells), monocytes, eosinophils, basophils: inc migration to lymphoid tissue

2) vasoconstriction via mast cell degranulation suppression: dec His release and capillary permeability

6

list the anti-inflammatory effects of hydrocortisone (glucocorticoids)

1) inhibits phospholipase A2 (via **annexin I activation) --> blocks arachidonic acid release (for PGs mainly + LTs, Txs)

-dec COX2 synthesis (via **NF-(kappa)B inhibition) --> dec PGs, Txs

-activates MAPK phosphatase I (inhibits MAPK proinflammation signals)

7

Hydrocortisone, 'other' effects:
-(1) CNS
-(2) other hormones
-(3) GI
-(4) blood
-(5) renal
-(6) fetus

1- behavioral changes: insomnia, euphoria --> depression

2- suppresses ACTH, GH, TSH, LH (chronic use)

3- peptic ulcers: gastric acid stimulation (+ H pylori immune response suppression)

4- inc platelets, RBCs

5- improves function (impaired with cortisol deficiency)
6- fetal lung development

8

Hydrocortisone:
-(short/long) duration of action
-(good/poor) skin diffusion
-(good/poor) mucous diffusion
-(strong/weak/no) salt retaining effects

1- short
2- poor
3- good
4- weak

9

corticosteroid agonists =

glucocorticoids
mineralocorticoids

10

list the glucocorticoids

prednisone
hydrocortisone
dexamethasone
beclomethasone
triamcinolone
methylprednisolone

11

list the mineralocorticoids

aldosterone
fludrocortisone

12

list the metabolic effects of hydrocortisone

1) Inc Gluconeogenesis and Glycogen Storage
-glycogen for availability in SNS activation for brain stores
-inc serum glucose
-inc insulin release, but inhibits muscle cell uptake

2) protein catabolism --> release of AAs

3) lipolysis --> fat deposition and redistribution + free FA and glycerol release

**Net- maintains glucose levels and stores for brain