L35- Steroid Pharmacology (gluco/mineralo-corticoids) Flashcards Preview

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Flashcards in L35- Steroid Pharmacology (gluco/mineralo-corticoids) Deck (11)
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1

list the synthetic glucocorticoids

prednisone
methylprednisolone
dexamethasone
beclomethazone
tramcinolone

(natural = hydrocortisone)

2

Synthetic Glucocorticoids:
-(slow/rapid) absorption + (short/long) duration of action
-(few/many) routes of administration
-(more/less) salt retaining effects than hydrocortisone

1- rapid, long (1/2 life)
2- many: IV, IM, topical, aerosol, intra-articularly
3- less

3

list the synthetic glucocorticoids by route of administration

Oral- all
IM- all
IV- all except triamcinolone
Topical- all except prednisone
Aerosol- only beclomethasone, trimacinolone

4

list effects of aldosterone receptor activation

(kidney)
-inc Na+/K+ ATPase expression
-inc ENaC expression
(inc Na reabsorption)

5

Aldosterone:
-regulated via (1) in the body
-(2) main effects

1- RAAS, CRH, ACTH

2- helps control water volume and electrolytes:
-Na reabsorption
-K/H excretion

6

list the mineralocorticoids

aldosterone

fludrocortisone (synthetic): more commonly prescribed

7

mineralocorticoid AEs

-hypokalemia, metabolic alkalosis
-inc plasma volume --> HTN

8

list the short to medium acting glucocorticoids (include anti-inflammatory and salt-retaining influence)

Hydrocortisone: baseline

Prednisone: good anti-inflam, poor salt

Methylprednisolone: good anti-inflam, poor salt

9

list the intermediate acting glucocorticoids (include anti-inflammatory and salt-retaining influence)

(hydrocortisone as baseline)
triamcinolone: good anti-inflam, NO salt

10

list the long-acting glucocorticoids (include anti-inflammatory and salt-retaining influence)

(hydrocortisone as baseline)
Dexamethasone: great/best anti-inflam, NO salt

11

list the mineralocorticoids (include anti-inflammatory and salt-retaining influence)

(hydrocortisone as baseline)
aldosterone: poor anti-inflam, strongest salt

fludrocorticosone: good inflam. great salt