Flashcards in Lang High Yield Pharmacology Deck (20):
What is a bactericidal Drug
One that can eradicate an infection in the absence of host defenses mechanisms; it will kill bacteria
What is a bacteriostatic drug ?
An antimicrobial drug that inhibits antimicrobial growth but requires host defense mechanisms to eradicate the infection
What is a Beta Lactam Drug ?
Drugs with structures containing a beta lactam ring including penicillins cephalosporins and carbapenems. The ring must be intact for the drug to work
What is a MIC
The lowest concentration of antimicrobial drug capable of inhibiting growth of an organism in a defined growth medium
What is a transpeptidase
A bacterial enzyme that is required for the cross linking of the bacterial cell wall
Can you kill a methicillin - resistant Staphlococci with infection with penicillin ?
No no class of penicillin can kill this bug
What are the narrow spectium penicillinase resistant penicillins
Mehticillin, oxacillin, and naficillin
What are cephalosporins ?
Beta Lactam drugs that act like penicillins but are more acid stable and can be taken with food. They are divided into 4 generations.
What would you use a first generation Cephalosporin for ?
Gram Positive Cocci E.Coli and Pneunomia
*Used for surgical prophylaxis
What would you use a second generation cephalosporin for ?
These have slightly less gram + activity and extended gram - activity. These are effective against anaerobic bacteria in sinus ear and respiratory infections
What would you use a third generation cephalosporin for ?
A resistant gram - infection such as beta lactamase producing nicceria and influenza
What is vancomycin ?
It is a bacteriocidial drug that binds to D-ala D-ala and inhibits transglycosylation which interferes with cross linking
Can a first generation cephalosporin be sued to treat meningitis ?
No because it can not cross the blood brain barrier
How is penicillin G administered ?
Im injection it can not be taken orally
Are penicillins susceptible to gastric acid ?
Yes they will be degraded by gastric acid
In addition to binding to Transpeptidase to inhibit cross linking in the bacterial cell wall what other function do penicillins have ?
They are autolysins which will break down the microbial cell wall
What is a sterol unique to fungal membranes
What are the primary drugs used to treat fungal infections ?
Amphotericin B and the Azoles
What is the mechanisms the Azols use to impede bacterial growth ?
Interfere with fungal cell membrane permeability in inhibiting the synehtsis of Ergosterol