Large Intestine Structure and Function Flashcards

1
Q

What is the pathway of the junction between the small intestine and the large intestine

A

Chyme moves from Illieum through ileocaceal valve into the caesum (blind sac)

The caecum, then drains into the large intestine or can then drain down into the appendix and lymph nodes below,

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2
Q

What is the four colon parts of the Large intestine

A

Ascending
Transverse
Descending
Sigmoid

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3
Q

How is the muscularis externa composed in the large intestine

A

A complete layer of circular muscle

Surrounded by an incomplete layer of Longitudinal muscle
consisting of 3 narrow bands of smooth muscles called Tenia coli

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4
Q

What affect does the Tenia Coli have on the large intestine

A

The teniae coli contract lengthwise to produce the haustra, the bulges in the colon

Pouches from give a puckered appearance

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5
Q

What is the mucosa composed of in the large intestine

A

Simple columnar epithelium

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6
Q

What is present in the large straight crypts found in the submucosa layer of the large intestine

A

Goblet cells

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7
Q

What is the purpose of Goblet cells on the large intestine

A

Produce mucus, which allows lubrication for the movement of faeces

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8
Q

Where is the rectum located

A

Between sigmoid colon and anal canal

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9
Q

What is the structure of the rectum

A

Straight muscular tube composed of simple columnar epithelium

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10
Q

Where is the anal canal located

A

Distal to the rectum and anus (2-3cm)

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11
Q

What is the mucularis externia of the rectum and the anal canal compared to the remainder of the alimentary tract

A

Thicker

But anal canal is even thicker due to the presence of the internal anal spinchter

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12
Q

What is the change in the mucosa layer in the anal canal

A

Changes from simple columnar to stratified squamous epithelium

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13
Q

How is the colons of the large intestine involved in nutrient absorption

A

They aren’t involved

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14
Q

What is the function of the colon

A

Form solid faecal pellets

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15
Q

How is solid faecal pellets formed in the colon

A

Sodium is actively transported from the lumen and into the blood, so water follows osmotic gradient out into the blood, the removal of water dehydrates the chyme creating the solid formation of faeces

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16
Q

What is the benefit of the long residence time of chyme in the large intestine

A

Allows time for bacterial colonisation of colonic microflora

17
Q

What is the function of colonic microflora in the colon

A

Bacterial fermentation of undigested carbohydrates

18
Q

What is the major benefit of colonic microflora in the colon

A

Produce additional energy source in short chain fatty acids

Produces Vitamin K which is needed for blood clotting

Produces Flatus

19
Q

What controls the internal and external anal spinchters

in the anus

A

Internal - smooth muscle under autonomic control

External - skeletal muscle under voluntary control

20
Q

What is the pathway occurring in the large intestine before defaecation occurs

A

After a meal there is a Mass movement of contraction from colon to rectum - this moves faecel into the rectum and distends the rectal wall upon arrival

This is senses by mechanoreceptors creating the defeaecation reflex, giving you the urge to defaecate

21
Q

What controls the defaecate reflex

A

Parasympathetic NS innervation the pelvic splanchnic

no sympathetic intervention

22
Q

What is the steps of the defeacation reflex

A

The stretched wall recoils and the rectum contracts

This causes the relaxation of the internal spinchter and the contraction of the external anal spinchters

Increasing the peristaltic activity in the colon

The increased pressure of the external anal spinchter
Under voluntary control is then relaxed and allows the explosion of faeces

23
Q

How does voluntary delay of defection occur

A

Voluntary contraction of external spinchter

24
Q

What happens to the toxins during constipation

difficulty emptying bowels

A

They are not reabsorbed but remain in faecal bulk

25
What can voluntary delay of defecation cause
Constipation | due to delay faeces harden up due to continually water absorption so are then harder to expel
26
What is the symptoms associated with constipation
Headaches Nausea Loss of appetite Abdominal distension
27
What directly causes the symptoms associated with constipation
The distension of the rectum due to the build up of material
28
What is the definition of Diarrhoea
Too frequent passage of faeces which are too liquid
29
What is the causes of Diarrhoea
``` Pathogenic bacteria Protozoans Viruses Toxins Foods Stress ```
30
What is examples of enterotoxigenic bacteria
Vibrio cholerae, Escherichia coli
31
How do enterotoxigenic bacteria cause detrimental diarrhoea
Produce protein enterotoxin bacteria that elevates intracellular secondary messengers that increase intestinal chloride secretion from crypt cells Due to to increased osmotic gradient this increases H2O secretion that swamps absorptive capacity of villus cells therefore resulting in profuse watery diarrhoea
32
Why is death a possibility in diarrhoea
As your body cannot tolerate that much fluid loss
33
What are the secondary messengers that enterotoxigenic bacteria micmic their physiological mechanism to produce an exaggerated stimulation
cAMP cGMP Calcium
34
What affect does enterotoxins have on villus cells
No effect - no damage
35
What is the treatment for diarrhoea
Oral rehydration therapy (ORS) | which is a sodium/ glucose solution
36
What is the purpose of the diarrhoea treatment
Rehydrate - by driving H2O absorption Wash away infection
37
What is flatulus composed of
``` Nitrogen CO2 Hydrogen Methane Hydrogen sulphide ```