Learning and Memory Flashcards

1
Q

Learning

A

Lasting change in behaviour resulting from experience

Acquiring new information and skills

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2
Q

Learning - Forms, Classical Conditioning, Pavlov

A

Pairing of two stimuli causes a change in response to one

Dogs study

Unconditioned stimulus produces an unconditioned response
Pairing UCS with a neutral stimulus produces UCR
After multiple pairings, NS will produce the CR without need for the UCS

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3
Q

Learning - Forms, Operant Conditioning, Skinner

A

Responses followed by reinforcement or punishmenet will be strengthened or weakened respectively

Rat study

Trained rats to press a level for food or avoid an area using shocks

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4
Q

Learning - Forms, Delayed Responses

A

Happenings which affect much later behaviour

e.g. eating a poisonous berry, being ill and then being averse to the berries forever

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5
Q

Learning - Forms, Insightful Behaviours

A

Searching or problem-solving to gain reward

e.g. monkey using a tool to get food from a box

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6
Q

Learning - Forms, Imitation

A

Copying of others behaviour

e.g. birdsong (not paired with reward)

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7
Q

Learning - Mechanisms, Pavlov

A

Conditioning strengthens to connections between the newly conditioned stimulus and usual unconditioned response via the original unconditioned stimulus

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8
Q

Learning - Mechanisms, Lashley 1930

A

If learning is a result of neural connections, a knife cut should abolish the learning
If specific connections explain learning of specific information, the size of physical damage should be proportional to the amount of retardation caused

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9
Q

Learning - Mechanisms, Lashley 1930, Mass Action

A

Assumption that the cortex works as a whole

If more of the cortex is active, learning will be more effective

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10
Q

Learning - Mechanisms, Lashley 1930, Engram

A

The physical representation of learning within the brain
e.g. the synapse connection

Located in the cortex

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11
Q

Learning - Mechanisms, Lashley 1930, Equipotentiality

A

All of the cortex contributes to learning equally, so much so that if one area were the be damaged, other areas can compensate for its function

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12
Q

Learning - Mechanisms, Thompson 1986, Engram

A

The engram of learning is located in the cerebellum

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13
Q

Learning - Mechanisms, Thompson 1986, Lateral Interpositus Nucleus

A

Inhibition of the LIN inhibits learning
When learning is suppressed, LIN shows no activity

Activity in LIN is required for retention and extinction of information

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14
Q

Learning - Mechanisms, Thompson 1986, Red Nucleus

A

Important for showing a learned response

Unsure whether you still learn implicitly as it cannot be shown

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15
Q

Memory

A

Process of acquiring knowledge and skills manifested in behavioural changes, based on an ability to retain what is learned

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16
Q

Memory - Encoding

A

Receiving, processing and combining information

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17
Q

Memory - Storage

A

Permanently recording encoded information

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18
Q

Memory - Retrieval, Recall, Recollection

A

Being able to call back the information from storage

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19
Q

Memory - Short-Term Memory, Hebb 1949

A

Holds information that has just been given for around 20-30 seconds

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20
Q

Memory - Short-Term Memory, Atkinson & Shiffrin 1968

A

All information must go via STM and be rehearsed before being consolidated to LTM

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21
Q

Memory - Working Memory, Baddeley & Hitch 1994

A

Temporary storage of information that is activley attended to and able to be worked on for a period of time

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22
Q

Memory - Working Memory, Chafee & Goldman-Rakic 1998

A

Delayed response task with single-unit neuron recording in parietal and prefrontal cortex

Shows that parietal activity can compensate for other areas of the brain during learning and memory consolidation

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23
Q

Memory - Working Memory, Hedden & Garbiela 2004

A

Lateral prefrontal cortex, primary visual cortex and hippocampus volume decrease with age

Can explain memory decline

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24
Q

Memory - Working Memory, Rosen et al 2002

A

Older individuals with intact memory show greater activity in lateral PFC, primary visual cortex and hippocampus

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25
Q

Memory - Declarative

A

Knowledge of facts requiring conscious awareness

Fast learning with little repetition
Verbally expressed

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26
Q

Memory - Procedural

A

Implicit knowledge of skills and abilities

Slow learning requiring much repetition
Expressed in performance

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27
Q

Memory - Episodic

A

Personal experiences and events, including the emotions and sensations of the occurrence

28
Q

Memory - Semantic

A

Facts of the world not related to specific events

e.g. word meanings

29
Q

Memory - Amnesia

A

Loss of memory

30
Q

Memory - Amnesia, HM

A

Removal of hippocampus

Difficulty forming LTM
STM and WM intact

Poor declarative memory
Intact implicit memory

31
Q

Memory - Amnesia, HM, Milner 1958

A

HM could remember a string of numbers by creating abstract strategies (procedural memory) to help remember them

If put under cognitive load or distracted, recall was not possible due to inability to consolidation the string

32
Q

Memory - Amnesia, Shrager et al 2008

A

Damage to medial temporal lobe left WM intact

If tasks were dependent on LTM, patients extremely impaired

33
Q

Memory - Amnesia, Retrograde

A

Loss of memories prior to brain damage

34
Q

Memory - Amnesia, Anterograde

A

Loss of ability to form new memories

35
Q

Memory - Amnesia, KC

A

Bilateral hippocampal lesion

Anterograde amnesia
Episodic amnesia

36
Q

Memory - Amnesia, KC, Rosenbaum et al 2005

A

KC able to use information about self from prior to incident but cannot form new memories or remember past experiences

Supports dissociation between episodic and semantic memory

37
Q

Memory - Amnesia, Tranel & Damasio 1993

A

Amnesia patients were exposed to a nurse (neutral / pleasant / unfriendly)
Later shown photos and will prefer the pleasant nurse
Cannot recall seeing the nurses

Implicit memory intact, declarative not

38
Q

Memory - Amnesia, Stickgold et al 2000

A

Amnesiacs played tetris and still had hypnagogic / dreaming experiences about the game despite not being able to recall playing

Lack of explicit, declarative memory

39
Q

Memory - Neural Basis, Amygdala

A

Involved in fear-conditioning

40
Q

Memory - Neural Basis, Parietal Lobe

A

Active when associating details of memories
Active during EWT

Damage results in poor episodic memory during spontaneous elaboration

41
Q

Memory - Neural Basis, Temporal Lobe

A

Hub for communication between regions of the brain

Linked to semantic dementia

42
Q

Memory - Neural Basis, Hippocampus

A

Link between amnesia and hippocampus damage suggests its involvement in memory

43
Q

Memory - Neural Basis, Hippocampus, Zola et al 2000

A

Dmaage impairs matching-to-sample tasks showing impaired episodic, declarative memory

44
Q

Memory - Neural Basis, Hippocampus, HM

A

Could not rememeber completing tasks e.g. mirror drawing

Skill improved due to procedural memory

45
Q

Memory - Neural Basis, Hippocampus, Spatial Memory, Goodrich-Hinsaker & Hopkins 2010

A

Radial maze for rats

Rats failed to navigate the same maze multiple times if had hippocampus damage

Simulated to find same results if using VR on humans

46
Q

Memory - Neural Basis, Hippocampus, Spatial Memory, Maguire et al 2000

A

Taxi drivers, who rely heavily on spatial memory, show enhanced hippocampus activity and volume

47
Q

Memory - Neural Basis, Hippocampus, Contextual Memory, Kamarowski et al 2009

A

Individual neurons respond to specific contexts

48
Q

Memory - Neural Basis, Hippocampus, Protein

A

Inhibition of hippocampul protein impairs memory consolidation

Enhanced release of cortisol during emotional events results in amygdala and hippocampal activity
Emotional events are remembered better

49
Q

Memory - Neural Basis, Basal Ganglia

A

Resembles a horn
Composed of globus pallidua, putamen and caudate nucleus

Associated with planning of motor movement and coordination, important in procedural learning

Damage results in Parkinson’s and inability to learn implicitly

50
Q

Memory - Neural Basis, Basal Ganglia, Moody et al 2010

A

Demonstrated the role of basal ganglis in implicit habit learning

Parkinson’s patients, who have inability to learn implicity, only learned a technique if they showed awareness of participating
If they were not aware they could not learn due to inability to have learned implicitly also

51
Q

Memory - Neural Basis, Prefrontal Cortex

A

Linked to reward choice comparisons and memory suppression

Impact on classical conditioning

52
Q

Memory - Neural Basis, Prefrontal Cortex, Depue et al 2007

A

Memories are suppressed by different areas of prefrontal cortex

Inferior PFC suppresses sensory memories
Medial PFC suppresses emotional memories

53
Q

Memory - Biochemical Mechanism

A

Patterns of neural acitivty leave paths in the brain for physical change

54
Q

Memory - Biochemical Mechanism, Hebbian Synapse

A

Simultaneous presynaptic and postsynaptic activity strengthens the effectiveness of a neuron

55
Q

Memory - Biochemical Mechanism, Hebbian Synapse, Long-Term Depression

A

Prolonged decreased sensitivity

Possibly due to extended understimulation

56
Q

Memory - Biochemical Mechanism, Hebbian Synapse, Long-Term Potentiation

A

When axons are bombarded with stimulation they become more responsive and synapses remain potentiated (with neurotransmitters) for a longer time

Dependent on glutamate

57
Q

Memory - Biochemical Mechanism, Hebbian Synapse, Long-Term Potentiation, Assumptions

A

Specificity where only active neurons are strengthened to improve efficiency
Associativity where weak inputs are paired with stronger ones to enhance neuronal responses by summation
Cooperativity where simulataneous stimulation increases LTP by summation

58
Q

Memory - Biochemical Mechanism, Glutamate Synapse

A

Glutamate is an excitatory neurotransmitter

59
Q

Memory - Biochemical Mechanism, Glutamate Synapse, AMPA

A

Glutamate receptors which open Na+ channels to allow cell depolarisation

60
Q

Memory - Biochemical Mechanism, Glutamate Synapse, NMDA

A

Glutamate receptors which open Na+ channels to allow cell depolarisation
Also open Ca++ channels if membranes are already polarised, triggerring neurotransmitter release

61
Q

Memory - Biochemical Mechanism, Glutamate Synapse, Magnesium

A

Blocks NMDA receptors at resting potential so no neurotransmitter is released and postsynaptic membranes cannot be stimulated

Is blocked from NMDA receptors at excitation threshold, allowing postsynaptic stimulation

62
Q

Memory - Biochemical Mechanism, Glutamate Synapse, Ca++

A

Allowed into the cell after Mg+ is blocked from NMDA receptors

Triggers CaMk11 proteins (e.g. CREB) in the nucleus to alter gene expression, which alters glutamate responsivity

63
Q

Memory - Biochemical Mechanism, Glutamate Synapse, Gene Alteration

A

Caused by CaMk11 / CREB

Increase glutamate release, dendrite number, AMPA sensitivity, increasing postsynaptic stimulation

64
Q

Memory - Biochemical Mechanism, Glutamate Synapse, Postsynaptic Stimulation

A

Excessive stimulation causes release of retrograde neurotransmitters

65
Q

Memory - Biochemical Mechanism, Glutamate Synapse, Retrograde Neurotransmitters

A

Modify presynaptic membranes
Decrease excitation threshold so AP are sent by weaker stimulation
Increase neurotransmitter release from more sites meaning more in the synapse for longer, resulting in LTP
Expand axons to fit more Na+ channels to allow more AP to fire