Lec 20 Pulmonary Thromboembolism Flashcards Preview

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Flashcards in Lec 20 Pulmonary Thromboembolism Deck (38):
1

What is pulmonary thromboembolism?

movement of blood clot from systemic vein through R side of heart to pulmonary circulation

2

What is common source of thrombi to lung?

usually from lower extremities; rarely from arms, pelvis, R chambers of heart

3

What is virchow's triad of risk factors for thrombosis?

- hypercoagulability
- damage to endothelium of vessel wall
- stasis/stagnation of blood flow

4

What are some hereditary risk factors for hypercoagulability?

- antithrombin deficiency
- protein C deficiency
- protein S deficiency
- factor V leiden
- prothrombin gene mutation

5

What are acquired risk factors for hypercoagulability?

- advanced age
- previous venous thromboembolus
- cancer
- obesity
- surgery
- immobilization --> long flight
- pregnancy
- estrogens
- having a catheter

6

What is factor 5 leiden?

- single base substitition --> factor Va resistant to action of protein C

het individuals have 3-5x increase risk of venous thromboembolism

7

What happens in prothrombin gene mutation?

G20210A mutation in untranslated region of prothrombin

het individuals have 30% increase in prothrombin and 2-3x increase risk of thromboembolism

8

What are sequalae of pulm embolism?

- have hemodynamic perturbations and impaired gas exchange

b/c mechanical obstruction of vessels + thrombus releases mediators

9

How does PE cause vasoconstriction?

thrombus releases mediators serotonin and thromboxane A2 causes vasoconstriction

10

What 3 factors determine the hemodynamic effects of PE?

- degree of cross sectional reduction of pulm vascular bed
- preexisting status of cardiopulm system [worse if high pulm pressure to start]
- physiologic consequences of hypoxic and neurohumorally mediated vasoconstriction

11

What happens if obstruction < 20%?

normal PAP and PVR b/c of recruitment and distension of pulm vessels
CO maintained

12

What happens if obstruction 30-40%?

increase PAP and modest increase RAP

13

What happens if obstruction > 50%?

compensatory mech overcome
CO begins to fall and RAP increases

14

What is maximum mean PAP right ventricle can generate in patient without prior cardiopulm disease?

40 mmHg

15

What happens to PaCO2 level in PE?

have increase dead space ventilation but also have increase in total minute ventilation

--> can get low CO2 [hypocapnia]

16

What are 5 mechanisms that can lead to hypoxemia?

- hypoventilation
- V/Q mismatch
- shunt
- diffusion impairment
- low PIO2

17

Does dead space ventilation cause hypoxemia?

nope! not on its own

18

How do you get hypoxemia due to decrease CO in pulm embolism?

have decrease CO --> decrease O2 delivery but your tissues still taking up the O2 and consume it --> lower O2 sat --> decrease CaO2

19

What are 4 mechs causing hypoxemia in pulm embolism?

- increased PVR
- decreased CO reducing the O2 in venous admixture
- loss of pulm surfactant
- bronchoconstriction

20

What is mech of increase PVR causing hypoxemia in PE?

- increased PVR --> causes increased perfusion to poorly ventilated areas and get V/Q mismatch + if really high PVR --> can get reverse shunt

21

What is mech of loss of surfactant causing hypoxemia in PE?

-loss of pulm surfactant after 24 hrs of occlusion --> atelectasis and edema

hypoxemia if partial thrombus resolution of perfusion but now have lack of ventilation = shunt

22

What is mech of bronchoconstriction in PE?

platelet mediators in thrombus cause vaso/bronchoconstriction

hypocapnia that occurs in PE also causes bronchoconstriction

23

WHat are the 3 potential sources of O2 for pulmonary parenchyma?

- airways
- pulm arteries
- bronchial arteries

24

What are symptoms of PE?

- acute onset dyspnea [most common]
- pleuritic chest pain
- hemoptysis
- syncope [rare]

25

WHat do you see in phyiscal exam with PE?

- tachycardia, hypotension, tachypnea, hypoxemia

- lung exam may be normal or may have rales, wheezing, findings of pleural effusion

- cardiac: RV heave, split S2, loud P2, systolic TR murmur

- extremities: tender, edema, palpable cord in vessel

26

What is hampton's hump?

shallow wedge-shaped opacity in periphery of lung with its base against pleural surface

represents lung infarction

27

What is westmark's sign?

localized area of decreased lung vascular markings

28

What are advantages/ disadvantages of CT pulmonary angiography?

advantages: high quality visualization; quick

disadvantages: radiation exposure, requires IV contrast

29

What is a ventilation perfusion scan?

perfusion: use radiolabeled macroaggregated albumin particle injected into peripheral vein; lodges in small vessels that are perfused

ventilation: inhale xenon radioisotope; asses which parts of lung ventilated

30

What is use of lower extremity ultrasound in pulmonary thromboembolism?

- if have DVT the vein will be non-compressible

if no thrombus --> will be able to compress easily

31

What is D dimer test?

tests if you have any forming clots --> will have positive D dimers of fibrin that break down when you give plasmin

32

What does positive D Dimer test tell you? negative?

positive = doesn't tell you much = poor specificity

negative = very sensitive and tells you that its probably not a thrombus

33

What is natural history of thromboembolism?

- thrombus grows, propagates; have fibrinolysis or roganization/recanalization

resolves a lot in first week; gradual over next 4-8 wks

most pts able to restore normal pulm hemodynamics + gas exchange

34

What is treatment for thromboembolism?

- anticoagulation
- thrombolysis or surgery in big thromboembolus

35

What are some examples of anti-coagulants?

- heparin
- warfarin
- coumadin

36

What are some examples of thrombolytics?

- tPA
- streptokinase
- urokinase

37

What is IVC filter? side effect?

- traps thrombi from lower extremities en route to pulm circulation

increases risk of deep vein thrombosis

38

What are indications for IVC filter?

- if contraindicated to anticoagulant therapy
- if thromboembolism recurs despite anticoagulation
- if limited pulm vascular reserve [already have pulm HTN]