Lec 75 Mood stabilizers Flashcards Preview

Brain And Behavior Exam 4 > Lec 75 Mood stabilizers > Flashcards

Flashcards in Lec 75 Mood stabilizers Deck (7)
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1

What is a mood stabilizer?

- intervention effective in treating acute mania and depression

2

What phases of illness can mood stabilizers treat?

- acute depression
- acute mania
- acute mixed state
- maintenance [prevention depression and mania]

3

What are pharmacokinetics of lithium?

- GI absorption
- not protein bound
- not metabolized
- filtered at glomerulus and reabsorbed by prox tubule
- excreted in urine
- 1/2 life 20-24 hrs [reaches stead state plasma level 4-5 days]

4

Which drugs affect lithium excretion?

increase excretion: carb anhydrase inhibitors, osmotic diuretics

decrease excretion: lasix, NSAIDS, tetracycline, cyclosporine, ACE inhibitors

5

What are side effects of lithium?

LMNOP
lithium --> movement [tremor], Nephrogenic diabetes insipidus, hypOthyroidism, Pregnancy problems

- effect on tubular function, glomerulus, lithium induced nephropathy

6

How do you treat lithium tox?

stop drug, give IV hydration
may need dialysis

7

What is goal blood level for lithium?

blood level = 0.6-1.2 mEq/L for mania; 0.4-0.8 for augmentation

check level + renal + thyroid function every 6-12 mo