Lecture 1 Flashcards
(20 cards)
virus
latin for “poison”
can refer to just the genome
proved TMV (virus) was filterable
1890 Beijerinck
Lwoff 4 criteria
- possessing only 1 type of nucleic acid
- multiplying in the form of their genetic material
- unable to grow or undergo binary fission
- lacking an enzyme system
Luria and Darnell
viruses replicate in living cells using the cells machinery to creates elements that can transfer the viral genome to other cells
virions
specialized elements- infectious viral particles
can be defective
extracellular state of a virus
capsid
protein coat
neucleocapsid
nucleic acid and capsid
some have outer layer called
phospholipid envelope
requires from cell
- enzymes for biosynthesis
- ATP
- ribosomes and enzymes for proteins synthesis
- membranes for compartmentalization and envelope synthesis
variolation
infecting a person with a mild version of the disease
vaccination
injecting a person with heat killed virus
Pasteur
vaccination against rabies
neucleocapsin shape
cone shaped
retroviruses
only family of virus that is diploid
pleomorphic
virus changes shape
ghosts
virus capsid that contains no nucleic acids
pseudovirus
contain cellular DNA
mutated strains
noninfectious or not viable
Baltimore classification
Class I - dsDNA
Class II - ssDNA
Class III - dsRNA
Class IV - +ssRNA
Class V - -ssRNA
Class VI - diploid +ssRNA with reverse transcriptase
Class VII (or Ia) - DNA with reverse transcriptase
other small infectious agents
non complex, one type of molecule
plasmids - dsDNA
viroids - circular ssRNA
prions - proteins
Satelllite RNA molecules and satellite viruses
