Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Virology > Lecture 7 > Flashcards

Lecture 7 Flashcards

(55 cards)

Start Studying
1
Q

parvovirus DNA

A

ssDNA
+ or - hammerhead ends
Hammerhead portion is self-complimentary, double-stranded

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

parvovirus

A 
small
parvus- Latin for small
T=1
1-3 capsid proteins
Some display oncotropism- viruses that replicated more efficiently in tumor cells
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

parvovirus replication

A

cellular DNA polymerases make dsDNA from ssDNA when cell is in S phase
Assembly in the nucleus
Ruptures nuclear and plasma membranes at release

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

autonomous virus

A

does not require a helper virus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

dependovirus

A

requires a helper virus such as AAV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

defective parvovirus

A

requires helper virus: adeno or herpes vir
AAV integrates in genome if helper virus is not present
replication occurs if daughter cell infected with helper virus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

AAV (virus)

A

adeno-associated virus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

parvovirus B19 diseases

A

Fifth disease- 1 in 5 childhood exanthemas (rashes)

slapped face rash

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

parvovirus path

A

infects erythroid precursor cells

enters nasopharyngeal to bone marrow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

parvovirus incubation

A

6 days

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

parvovirus immune response

A

antibody with appearance of rash and aches

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

parvovirus Human B19 infectious stage

A

infects RBC’s and precursor cells in bone marrow
RBC production stops with death of precursor cells
viremia with flu-like symptoms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

human infecting parvoviruses

A

dependovirus- adeno-associated virus (AAV)

erythrovirus- B19 virus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

parvovirus transmission

A

respiratory droplets
children and parents
anemic patients
65% of adults have Abs to B19

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Parvovirus vaccine

A

none

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Adenovirus

A

first isolated from adenoids and tonsils
binds CAR- Coxsackie adenovirus receptor
some bind integrin proteins as 2^o R

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

adenovirus structure

A

T=25
11 proteins in virion
20 faces and 12 vertices with spikes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

adenovirus genome

A

dsDNA
terminal proteins
terminal inverted and repeats

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

adenovirus replicative cycle

A

attach to CAR or Integrin receptors
DNA enters nucleus via terminal protein
Control is at level of transcription
Uses Cellular RNA Pol II

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

adenovirus DNA replication

A

both strands are transcribed
overlapping genes
Cellular RNA Pol II transcrives most of mRNA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Adenovirus DNA synthesis

A

preterminal protein primes
synthesis by viral DNA polymerase
single-stranded is circularized

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

adenovirus incubation

A

9 days

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

adenovirus infects

Study These Flashcards
A

mucoepithelial cell in respiratory, GI, and conjunctiva

24
Q

adenovirus diseases

Study These Flashcards
A

pinkeye- conjunctivitis
GI infections
pneumonia
upper respiratory pharyngitis

25
adenovirus treatments
vaccine (for military) and CA therapies
26
adenovirus transmission
repiratory droplets, fecal, fomites, close contact, swimming pools
27
adenovirus human-infecting
~50 serotypes
28
poxvirus human-infecting
Variola (smallpox) | molluscum contagiosum
29
poxvirus structure
complex, oval, or brick-shaped surface ridges or tubules 2 infectious forms: mature virus (MV)- one lipid membrane Extracellular virus (EV)- two lipid membranes
30
poxvirus genome
``` dsDNA 150 to 250 proteins genes covalently closed ends on DNA genes on both strands each gene has own promoter ```
31
poxvirus replications cycle
``` fusion with plasma membrane may be phagocytized replication occurs in cytoplasm (unusual for DNA virus) RNA synthesis and processing in core early mRNA made in core all enzymes needed for transcription are in virion viral DNA synthesis with viral enzymes envelope forms are core in cytoplasm ```
32
poxvirus assembly in cytoplasm
crescent-shaped membrane structure form de novo, will become viral envelope lipids are deliver to crescents from the ER as small micelles crescents mature into spheres and enclose viroplasm
33
poxvirus release
mature virus is wrapped in bilayer membrane from Golgi membrane fuses with plasma membrane, virus remains attached to cell membrane actin tails form on virus while attached to membrane
34
poxvirus distinct characteristics
two forms: mature and extracellular virus
35
Mature poxvirus
stable, responsible for person to person trans. has outer envelope attaches to cellular gycosaminoglycans enter by fusion or endocytosis
36
extracellular poxvirus
fragile, responsible for cell to cell spread wrapped in additional lipid bilayer enters by phagocytosis or membrane ruptures making a mature poxvirus
37
poxvirus transmission
respiratory droplets, fomites, direct contact no seasonal viremic stages vaccine for smallpox
38
poxvirus diseases
smallpox (eradicated) cowpox Orf
39
poxvirus vaccination
15 strokes with bifurcated needle pustule in 6 - 11 days pustule in previously vaccinated in 3-4 days
40
herpesviruses
herpesviridae- greek herpein (creep) | 20% in USA have recurrent infections
41
herpesviruses structure
icosahedral capsid with tubular capsomers T=16 tegument proteins
42
herpesvirus genome
linear dsDNA cellular RNA pol II transcribes mRNA Some mRNA have introns
43
herpesvirus human affecting
9 including herpes simplex virus, varicella-zoster, epstein-barr, cytomegalovirus
44
herpesvirus attachment, penetration and uncoating
binds to nectin1 and herpesvirus entry mediator (HVEM) fusion with plasma membrane teguments proteins interact with cellular machinery to activate viral gene expression and degrade cellular mRNA by Vhs
45
Vhs
viral host shutoff (protein)
46
herpesvirus replication cycle
uncoated into the nucleus assembly of nucleocapsid in the nucleus bud into the ER and Golgi then vesicles to plasma membrane envelope from nuclear, ER, or Golgi most can form latent infections in neurons, B or T cells
47
Herpesvirus concatemers
DNA synthesis- DNA becomes circular rolling circle DNA synthesis DNA synth activates cyclin-dependent kinase cdc2 nucleocapsid assembles in the nucleus
48
herpes simplex virus latent infection
3 HSV proteins block apoptosis | viral RNAs made from introns, called LATs, accumulate in nucleus
49
Herpes simplex (disease)
HSV1- lesions near mouth HSV2- lesions in genital region replicates in skin or mucosal cells at entry site
50
herpesvirus transmission
body fluid into breaks in skin or eye direct contact no seasonal incidence latent infections
51
Herpesvirus simplex treatment
no vaccine many antiviral medications not neutralized by Ab
52
herpesvirus incubation
5-6 days
53
varicella-zoster virus
(herpesvirus) chickenpox- primary shingles- recurrent (latent) vaccine for chickenpox, can get shingles from vaccine (50/50)
54
cytomegalovirus
``` herpesvirus infects epithelial cells and others usually causes subclinical infections congenital infections no vaccine many antivirals ```
55
epstein-barr virus
Mono (infectious mononucleosis) latent infections in B cells B cells become immortal in tissue culture binds to CD21 or MHC II infects B cells and mucosal epithelial cells latent spread through body fluids, direct contact, fomites no seasonal incidence no vaccine

Virology (8 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions