lecture 1 Flashcards
(43 cards)
what secretes antibodies?
plasma cells
what mediates activation of CD4 helper T cells when encountering an antigen? (naive CD4 t helper cells + antigen =?)
Cytokine IL-2
what is the goal of vaccinations?
antibodies preventing an infection & memory
in what adaptive phase do clones die?
contraction phase
what immunity creates resistance but NO memory?
passive immunity
what immunity is an immunization/ giving of Ag’s
active immunity
what is a transfer of antibodies in plasm and a treatment for immunodeficiency?
passive immunity
what recognizes Ag’s and makes Ab secreting cells?
B cells
What needs an APC to recognize Ags?
T cells
what recognizes Ags on infected cells and then kills the cell?
cytotoxic T cells
what regulates self-antigens by suppressing & preventing immune responses?
Regulatory T cells
phagocytes include what?
Neutrophils & macrophages
what is the primary function of phagocytes
ingest/destroy microbes; get rive of damaged cells
what are the specialized macrophages and corresponding tissues?
brain: microglial
liver: kuppfer
lung: alveolar
spleen: sinusoidal
what lineage are DCs from?
myeloid in bone marrow
what are the 4 DC classes?
- classical
- plasymactiod
- inflammatory
- langerhans cells
what cells arise from the lymphoid lineage?
B cells
T cells
NK cells
what are primary lymphoid organs?
bone marrow & thymus
what are secondary lymphoid organs
spleen, lymph nodes, lymphoid tissues
HEV express _____1_____, that serve as _____2____ for lymphocytes
- adhesion molecules
2. homing receptors
all mast cell granules do what?
- induce local inflammation
- responsible for vascular abnormalities
- inflammation in allergic reactions
mast cell mediates produce and release what?
- cytokines
- chemokines
- angiogenic
- growth factors
where are mast cells located & why?
- close to external environment (skin)
- close to blood vessels
why– to regulate vascular permeability & effector - cell recruitment
what are the 3 lipid mediators for mast cells?
- prostaglandins
- leukotrienes
- platelet-activating factors