Lecture 1 Flashcards

1
Q

Human cells express 20% of their genes

A

True

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2
Q

Proteins are mutated

A

False. Genes are mutated. The product is an aberrant protein

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3
Q

The central dogma is DNA to RNA to amino acids

A

True

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4
Q

Genes can be switched on and off depending on the cells needs

A

True

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5
Q

Clb2 was originally found in a yeast

A

True. Saccharomyces

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6
Q

The domain in clb2 controls movement between nucleus and mitochondria

A

False. The nucleus and cytosol

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7
Q

The correct order of mitosis is prophase metaphase telophase anaphase

A

False. Prophase metaphase anaphase telophase

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8
Q

Initiation of m phase occurs due to cyclin B-cdc2 complex

A

True

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9
Q

Exit of m phase occurs due to cyclin E-CDK2 complex

A

False. It’s the cyclin D-CDK4/6 complex

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10
Q

Initiation of S phase uses cyclin E-CDK2 complex

A

True

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11
Q

Cyclins are present for the full length of a phase

A

False. They may not be

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12
Q

Checkpoint G1 is used to check for nutritional status of a cell

A

True

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13
Q

Checkpoint G2 is used to ensure chromosomes are attached to the spindle

A

False. It checks mutations and ensures the copy is correct

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14
Q

Mitosis checkpoint checks for mutations and ensures the copy is correct

A

False. It ensures chromosomes are attached to the spindle.

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15
Q

Tubules are made of myosin.

A

False. Actin

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16
Q

Cyclin b rapidly increases during mitosis to enable anaphase

A

False. It decreases to enable anaphase

17
Q

Cyclin B facilitates cytokinesis

A

True

18
Q

Kinases usually phosphorylate proteins

A

True

19
Q

Cyclin dependant kinases are enzymes

A

True

20
Q

CDKs must be bound to cyclins to become activated

A

True

21
Q

The NES helps cyclin E shuttle between the nucleus and cytoplasm

A

False. It’s cyclin B

22
Q

Site directed mutagenesis uses oligonucleotide primers that are 50-70 base pairs long

A

False. They are 10-30 base pairs long

23
Q

pP2189 has ampicillin resistance

A

True