Lecture 1 - derm Flashcards Preview

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Flashcards in Lecture 1 - derm Deck (27):
1

Which cells are responsible for Vit D synthesis?

Keratinocytes in the epidermis
- also synthesizes keratin

2

Which cells are involved in immunologic barriers?

langerhan cells

3

Which types of cells are involved in pheromones and body odor?

apocrine glands

4

Keratinocytes

1. forms barrier layer,
2. synthesize keratin (fibrous protein of skin),
3. synth Vit D
4. involved in proliferation,
5. differentation,
6. programmed cell death.

5

What is skin color variation due to?

Type of melanin produced and distribution of melanosomes
-NOT due to the # of melanocytes

6

Langerhans Cells:

□ Dendritic cells derived from bone marrow stem cell; found in small #s

□ Participate in cell-mediated immune reactions by behaving as an APC

7

Layers of the dermis

Q
Papillary layer (loose CT directly deep to the epidermis)

Reticular layer (deeper)

8

Which dermis layer provides blood supply for the epidermis?

Q

Papillary

- note: reticular layer serves as the pathway of major BVs arranged specifically to facilitate thermoregulation

9

Meissner's corpuscles
Pacinian corpuscles
- Where are they found?
- What do they do?

Meissner's corpuscles
- in papillary layer
- fine/tactile sense touch (fingertips)

Pacinian corpuscles
- in reticular layer
- sense vibration, pressure, and touch (gentitals ahhh yyeeaaaa)

10

cellular layers of skin

Chinese Ladies Give Superb Backrubs (superficial to deep)

1. Stratum corneum
2. Stratum lucidum (thick skin only)
3. Stratum granulosum
4. Stratum spinosum
5. Stra

11

Eumelanin
Pheomelanin

Eumelanin: black-brown pigment

Pheomelanin: yellow-red-brown pigment

12

Three ways you can get VIt D

1. Sun (UVB -> skin)
2. Diet (Ergocaciferl aka Vit D2)
3. Diet (Cholecaciferol aka Vit D3)

- These are then converted to Calcidiol by the liver
- Calcidiol is then converted to Calcitriol by the kidneys

13

UVB from the sun gets converted to what?

Cholecalciferol Vit D3
(same as the one from the diet)

14

Hemidesmosomes

attach basal cells to the basal lamina of dermal epidermal junction

15

Desmosomes

attach keratinocytes to each other

16

Pemphigus Vulgaris

- AutoAntibodies to desosome proteins
- Epidermis attaches fine to Dermis, but connection between keratinocytes suck
- Skin lesions are flaccid bulla.
(that 16 year old kid had it)

17

Tonofilaments

protein structures that insert into the cytoplasmic side of the plasma membrane of desmosomes

18

Bullous Pemphigoid

Antibodies to the hemidesmosomes.

Epidermis does not attach to dermis.

19

Basal keratinocytes
- what are they
- where are they located?

Stem cells of the epidermic
located in the bottom most stratum basalis (germinativum)

20

How long does it take to renew the epidermis?

28 days

21

Function of:
Stratum Basalis

Location of some cell attachments

22

Function of:
Stratum Spinosum

Reinforce the cytoskeleton

note: Synthesis of involucrin and membrane coating granules occurs here

23

Function of:
Stratum Granulosum

Contain different types of granules (ie: filaggrin)

24

What skin layer do cells no longer have nuclei or organelles?

Stratum lucidum *if present*

Or Stratum corneum

25

What skin layer is the entire cell filled with keratin?

Stratum corneum

26

What granules contain the filaggrin precursor? What layer of skin is it in?

Keratohyalin granules contain the filaggrin precursor

27

What layer does shedding of dead corneocytes occur? What is that called?

Stratum corneum is where Desquamification occurs.