Flashcards in Lecture 5 - derm Deck (20):
aka Capillary or Strawberry Hemangioma
○ Most common soft tissue tumor of infancy (10-12%); benign endothelial cell neoplasm
Systemic complications of infantile hemangioma
Kasabach-Merritt syndrome (a consumptive thrombocytopenic coagulopathy) and
high output congestive heart failure.
Port Wine Stain typically follows what distribution?
- 1/4 of adults have at least 1 - gross
Positive dimple "Fitzpatrick" sign
pinch lesion and should see slight downward movement of tumor
Barnacles of Life
Benign tumor of the hair follicle, distributed mainly in on the head, neck, trunk.
slightly raised, light brown to black papules or plaques.
melanocyte nests (nevus cells) exclusively within the ____________
dermis. (moles are intradermal)
how does it occur?
§ Dermal proliferation; produce lots of melanin
- Due to Tyndall Effect, blue color is reflected back (shorter wavelengths)
Endothelial Cell benign skin growth
○ Cherry Angiomas
○ Infantile Hemangioma: embolized placental cells or angioblasts that differentiate toward placental type.
○ Port Wine Stain
Sebaceous gland benign skin growth
Sebaceous Hyperplasia and Nevus sebaceous
Fibroblast benign skin growth
Melanocytes benign skin growth
café au lait macule
Dermatofibroma malignant potential if:
if presented as large and enlarging lesion, aka dermatofibrosarcoma protuberans (DFSP)
Seborrheic keratoses malignant potential if:
aka Sign of Leser Trelat, which is associated with adenocarcinoma of the stomach in 60%.
Congenital Nevi malignant potential if:
if >10 cm; can occur in 1:20,000 newborns, or if >20cm in older patients, 1% will have risk of malignancy. If malignant, 50% appeared in first three years.
Dysplastic Nevi malignant potential if:
Increased risk for development of melanoma if pt had family history of multiple dysplastic nevi melanoma
Recognize the fact that port wine stains are congenital vascular malformations.
- what is it?
- how does it present?
• Vascular malformation that is presented at birth and persists into adulthood; typically due to somatic mutation in GNAQ.
○ Presented as an overgrowth of an extremity covered by a large port wine stain.
○Complications can include varicose veins, venous stasis, edema, and ulceration.
Role of pharmacotherapy in treatment with Peramivir
Only for critically ill or immunocompromised
- NA inhibitor for Influenza A and B