Lecture 1 - Intro Flashcards
(68 cards)
define compounding
preparation, mixing, assembling, packaging, or labeling of drug or device as a result of practitioner’s prescription order or initiative based on pharmacist/patient/prescriber relationship
name 4 types of nonsterile compounding
- mixing 2 MANUFACTURED products
- diluting a liquid
- adding a flavor
- preparing solution, suspension, ointment, etc
true or false
adding water, syrup, or another vehicle to a highly concentrated digoxin solution is considered NONSTERILE compounding
true
if tablets cannot be swallowed, they are usually made into what dosage form and why?
SUSPENSION
tablets contain magnesium stearate as a lubricant, which is poorly water soluble. will never be able to make a total homogenous solution, so we make suspension
true or false
turning tablets into a suspension is not considered nonsterile compounding
false - it is
is adding a flavor considered nonsterile compounding
yes
give an example of sterile compounding
IV admixtures
what is a general reason for compounding
to provide individualized patient care by meeting the specific needs of each patient
how is compounding useful for veterinary use
can make a solid dosage form into a gel to put on the animal’s paw and they can lick it off
true or false
adding flavor to a medication to make it more appealing to a child is considered nonsterile compounding
true
how many categories of compounding are there?
7
name what each of the 7 categories of compounding are**
category 1 – nonsterile simple: mixing 2 commercial products (no calcs)
2 - nonsterile but complex. bulk drug or calcs required
3 - sterile - risk level 1 (low levels)
4 - sterile - risk level 2 (medium levels)
5 - sterile - ridk level 3 - high levels
6 - radiopharmaceuticals
7 - veterinary
each of the 7 categories of compounding is associated with….
specific training requirements for each
true or false
category 3 has higher risk levels than category 5
false - lower risk levels
1 liquid vial - transfering into IV bag
what is risk level?
give examples of other 2 risk levels as well
LOW - not high risk of contamination
probably category 3 (risk level 1)
if multiple vials, may be medium risk
high risk may be making TPN products (total parenteral nutrition) or complicated manipulations are involved
WHY is adding flavor to a manufactured product considered compounding?
because the BUD will change!!
is pyridostigmine suspension stored at room temp or fridge and what is BUD
35 days, room temp or fridge is fine
name 3 components of USP-NF
monographs
general chapters
general notices
between monographs, general chapters, and general notices all contained in USP-NF, which is used most of the time?
what is it used for?
monographs
used to understand the excipients and active ingredients.
includes a lot of things like the name, definition, packaging, labeling, and storage requirements,
what is contained in the “general chapters” of USP-NF
more detail on the test methods and procedures in the monographs
what is contained in the “general notices” portion of USP-NF
it’s like an appendix – provides definitions for terms used in the monographs
a prescription bottle is considered what type of container?
well closed container
what are the storage requirements for calcium citrate and what does this say about the stability of the ingredient
preserve in well-closed containers
the drug is probably pretty physically and chemically stable and won’t evaporate easily
USP chapters 795, 797, and 800
795 - nonsterile compounding
797 - sterile compounding
800 - hazardous drugs
