Lecture 10 Flashcards
5点non-specific/ innate immunity VS specific adaptive immunity
non-specific
first line, does not need to recognize the pathogen, same response
specific
require recognition, faster response when see the same pathogen again
3 kinds of discoveries in science & eg
accidents of nature
severe combined immune deficiency syndrom(SCID)
AIDS
leaps of faith
smallpox
serendipity=happy accident
Alexander Fleming, penicillin
primary component of immune system
primary
bone marrow& other sites of hematopoiesis: B cell mature& immature T cell
thymus: T cell mature
secondary component of immune system
secondary: most immune response occur
lymph node: through out body, filter microbe, macrophage in node phagocytize microbe
spleen: remove microbe& old erythrocyte
lymphoid nodule
tonsil, adenoid: respiratory tract
Peyer’s Patches: gut
MALT=mucosal associated lymphoid tissue
use of histamine
blood flow& allergic response
immune cell
lymphoid stem cell differentiate
T cell: cytotoxic T cell/ CD8+ & helper T cell/ CD4+ & regulatory T cell/ CD4+
B cell
natural killer cell
myeloid stem cell differentiate
granulocyte
eosinophils: destroy parasite
basophils: histamine
mast cell: histamine
histamine: blood flow& allergic response
neutrophil: phagocyte
monocyte: become macrophage and dendritic
first line of defense
physical barrier
skin
physical& mechanical
tight junction, mucus, hair, cilia
chemical
low pH sebum皮脂, saliva lysozyme break down bacteria CW, gastric juice break down bacteria
microbiological
normal flora
2 个second line of defense
humoral factor
cellular factor
4 humoral factor
inflammation& fever mobilize WBC to site of infection
antimicrobial susbtance
C reactive protein
complement
cytokine
interferon
iron binding protein/ transferrin
how interferon work
prevent viral in a nonspecific manner
cell infect w/ virus, detect infection
secrete type 1 interferon
receptor activated, produce antiviral protein
alternative pathway of complement
C3b bind to surface of bacteria/ opsonization
phagocyte have C3b receptor, stick to bacteria, recognize as foreign
C reactive protein作用
produce by liver, response to inflammation
iron binding protein/ transferrin作用
sequester Fe, difficult for bacteria to divide w/o Fe
