Lecture 10 Flashcards
(15 cards)
1
Q
How does sorting of proteins occur at TGN
A
- Storage / transport via clathrin coated vesicles
- Proteins tagged in Cis Golgi
- Phosphorylated mannose residues
- Rcognized or captures: Mannose 6 Phosphate receptors
2
Q
Role of Adaptin
A
- Create a bridge of adaptin
- induce Curvature
- Cargo selection and Cargo receptor
3
Q
what does tethering depend on
A
Rab protein
tethering protein
4
Q
Rab proteins
A
small G protein family
GTP bound = active
GDP bound = inactive
5
Q
SNARE prtoeins
A
For docking
Brings it close enough for fusion
v snare = vesicle
t snare = target
6
Q
2 types of t snares
A
- Syntaxin
- 2 SNAP 25
7
Q
V SNARE proteins
A
Synaptobrevin
8
Q
How many t snares and v snares interact
A
- 4 Proteins
9
Q
Luminal part
A
Extracellular surface of plasma membrane
10
Q
Cytosolic part
A
Intracellular surface
11
Q
Two types of Endocytosis
A
- Bulk phase
- Receptor mediated endocytosis
12
Q
main destination of endocytic pathway
A
lysosomes
13
Q
Lysosomes
A
is acidic
ATP and H+
14
Q
Peroxisomes
A
- Small membranous organelle
- Carrying out metabolic functions
- Transport proteins across membranes
- Synthesis on free ribosomes
- Imported posttranslationally
15
Q
A
