lecture 11 and 12: respiratory system Flashcards

1
Q

what causes pressure changes in the lungs

A

changes in thorax vol (pressure dif between atmosphere and lungs)

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2
Q

how do the lungs expand if there are no lung muscles

A

skeletal muscles of the thoracic wall/cavity are used

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3
Q

what lines the lungs

A

visceral pleura

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4
Q

what lines the inner surface of the thoracic cavity and rib cage

A

parietal pleura

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5
Q

what is the pleural cavity (intrapleural space) filled with

A

fluid to reduce friction created by lung movement during in/exhalation

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6
Q

what type of process in inhalation

A

active

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7
Q

whats the main inspiratory muscle and what does it do

A

diaphragm
-contracts and is drawn downwards and becomes flat (phrenic nerve innervation)

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8
Q

what do external intercostals do during inspiration

A

contract raising ribcage up and out

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9
Q

what does the chest cavity do during inspiration

A

expand and lungs pulled outwards- thoracic vol increases

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10
Q

what does elevation of the ribs cause

A

sternum moves up and out- increases front to back dimension of thoracic cavity

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11
Q

what happens to alveolar pressure during inspiration

A

drops below atmospheric pressure- air flows into lungs until alverolar pressure=atmospheric pressure

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12
Q

what kind of process is exhalation

A

passive

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13
Q

what does the diaphragm do during expiration

A

relaxes and moves upwards (decreased vertical size of chest)

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14
Q

what do EIM do during expiration

A

relax and moves in and down (decrease chest diameter)

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15
Q

what happens to chest cavity during expiration

A

vol reduced and pressure increases

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16
Q

what happens to expiratory muscles during forced active expiration

A

contract to further reduce volume of thoracic cavity and thus lungs

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17
Q

what happens to abdominal muscles during forced active expiration

A

contract forcing diaphragm further into thoracic cavity

18
Q

whats only active during forced active expiration and what do they do

A

IIM and they contract pulling ribs down and in

19
Q

what forms the bottom of the thoracic cavity

20
Q

why do lungs recoil on expiration

A

elastic fibres in alveolar wall stretch and shorten

21
Q

what happens to water molecules on the alveolar surface

A

they have a strong attractive force for one another= surface tension which promotes collapse of smaller alveoli and an irregular rate of shrinking

22
Q

how to minimise effects of surface tension on pulmonary ventilation

A

surfactant

23
Q

what is surfactant secreted by

A

type 2 alveolar epithelial cells

24
Q

how do surfactants work

A

detergent like substance that lowers surface tension and increases lung compliance (more controlled recoil)

25
what is alveolar interdependence
each alveolus surrounded by other alveoli- if 1 collapse, surrounding ones pulled in direction of caving-in alevoulus
26
repiratory work
70%- overcome recoil tendency 30%- overcome airway resistance
27
where is airway resistance greatest
mid-size bronchi
28
airflow rate (F) equation
pressure gradient (delta P) / airway resistance (related to radius)
29
what is partial pressure of a gas directly proportional to
its concentration (diffuses from high to low partial pressures)
30
what is each alveolus encircled by
dense network of pulmonary capillaries
31
what factors affect gas transfer rates
1. HR- increased perfusion of alveoli 2. resp rate- alveloli ventilation increases 3. environment- conc of gas in inspired air can change
32
what is PO2
measure of dissolved oxygen in blood, not of total o2 in blood
33
how many RBCs per ml of blood
5B
34
erythrocyte structure
-flat, disc-shaped -indented in middle -non nucleated -no mitochondria or other organelles
35
key features of RBCs
-large SA -thin -flexible to fit through narrow capillaries -Hb
36
each haem group binds to what
single o2 molecule
37
2 parts of Hb
1. globin portion (4 highly folded polypeptide chains- each globin has a haem group) 2. 4 iron-containing, non-protein groups (haem groups)
38
what do each of the 4 Fe atoms bind to
1 o2 molecule
39
how many 02 molecules can Hb carry
max 4
40
what affects % Hb saturation
po2
41
+ve cooperativity
binding of each 02 to a given subunit increases 02 binding affinity of other subunits binding of 1st o2 molecule induces conformational change which makes binding of 2nd o2 easier - binding of the 2nd o2 induces further conformational change, which makes binding of 3rd o2 even easier