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Neurobiology > Lecture 13, part 2: Receptors > Flashcards

Lecture 13, part 2: Receptors Flashcards

1
Q

how many metabotropic glutamate receptors are there?

A

8

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2
Q

which glutamate receptors are ionotropic

A

AMPA, kaintate and NDMA

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3
Q

describe the structure of mGluRs

A

7 TM domains
dimers

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4
Q

LBD of mGluR is found in where?

A

extracellular matrix

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5
Q

which group houses mGluR1 and 5?

A

group 1

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6
Q

which group does mGluR2 and 3 belong to?

A

group 2

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7
Q

which metabotropic glutamate receptors are found within group 3?

A

4678

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8
Q

binding to metabotropic glutamate receptors 1 and 5 has what effect?

A

phospholipase C stimulation and PIP2 cleavage

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9
Q

mglur1

A

increase in intercellular calcium

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10
Q

mglur5

A

potassium outflux

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11
Q

group 2 and 3 have their effects by?

A

inhibiting adenylate cyclase

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12
Q

what effect do group 1 metabotropic receptors have postsynaptically

A

increase excitability via phosphorylation of different channels

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13
Q

what effect do group 1 metabotropic receptors have presynaptically

A

enhances glutamate release

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14
Q

what effect do groups 2 and 3 glutamate metabotropic receptors have

A

inhibitory

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15
Q

which group of glutamate receptors can also be found on gabaergic receptors

A

group 2

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16
Q

which glutamate receptors do glial cells express

A

5 and 3

17
Q

how can the effects of an agonist on metabotropic glutamate receptors be reversed?

A

antagonist addition

18
Q

effect of an antagonist of glutamate receptors

A

blocks hyperpolarisation

19
Q

AMPA receptors include

A

A1-A4

20
Q

kaintate receptors include

A

GluK1-Gluk5

21
Q

NMDA receptors include

A

GLuN1, N2A,N2B,N2C,N3A,N3B

22
Q

antagonist for AMPA

A

peramaphel

23
Q

kainate antagonist

A

UBP-302

24
Q

NDMA antagonist

A

Ap-5

25
Q

NMDA agonists

A

glutamate and aspartate

26
Q

NMDA is blocked by which drugs

A

ketmine
mg2+
pcp
mk801

27
Q

nmda co-agonist

A

glycine

28
Q

modulators of nmda receptors

A

magnesium and polyamines

29
Q

how many subunits make up ionotropic glutamate subunits?

A

4

30
Q

domains in each ionotropic subunit:

A

3 transmembrane domains and 1 membrane domain

31
Q

ionic movement via ampa receptors

A

sodium in and potassium out

Neurobiology (9 decks)

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