Lecture 14, drugs affecting serotonin

Question 1

why are 5Ht1 receptors inhibitory?

Answer 1

coupled to Gi/Go proteins which inhibit cAMP formation

Question 2

how does binding to 5-HT1 trigger hyperpolarisation?

Answer 2

activates GiRK

Question 3

along with 5-HT1A, which other receptor reduces serotonin release upon activation?

Answer 3

5-HT1B

Question 4

what is the effect of 5-HT1A and 5HT1b receptors on non-serotonergic receptors?

Answer 4

inhibit release of other neurotransmitters

Question 5

5-Ht1A/b receptor location

Answer 5

post and pre synaptically

Question 6

which channels are activated upon activation of 5-Ht1a/B receptors on post-synaptic membrane?

Answer 6

GiRk

Question 7

migranes can be treated with

Answer 7

serotonin receptor agonists

Question 8

how does sumatriptan exert its effects?

Answer 8

binds to presynaptic 5-HT1 receptors to inhibit proinflammatory peptide and neuropeptide release
binds post-synaptically to trigger vasoconstriction

Question 9

why is Lasmiditan suitable in treating migraines in those with vascular disease?

Answer 9

doesnt trigger vasoconstriction

Question 10

which drug targets 5-HT1F receptors

Answer 10

Lasmiditan

Question 11

migraine involved the activation of which sensory nerves?

Answer 11

trigeminal

Question 12

activation of 5-Ht3 receptors causes what movement?

Answer 12

inward movement of K, Na and Ca

Question 13

release of serotonin, CCK, gabba and dopamine is triggered by activation of what kind of serotonin receptor?

Answer 13

presynaptic 5-HT3

Question 14

where are post synaptic 5-HT3 receptors located?

Answer 14

hippocampus

Question 15

how does ondansetron prevent drug-induced vomiting

Answer 15

5-HT3 receptor antgagonist
prevents activation vagal afferents in periphery

Question 16

which central regions does ondanestron prevent the activation of in response to a cytotoxic drug?

Answer 16

area postrema and the nucleus tractus solitatus- vomiting centre not innervated

Question 17

why do SSRis cause an initial decrease in mood?

Answer 17

serotonin increase in the synaptic cleft activates autoreceptors which decreases serotonin release

Question 18

SSRIS inhibit

Answer 18

SERT

Question 19

activation of autoreceptors effect on 5HT

Answer 19

decrease levels
which decreases sensitivity of autoreceptors

Question 20

decreases amount of 5ht metabolites have been associated with

Answer 20

suicide and aggression

Question 21

low serotonin revels in those who tried to kill themseleves may be due to an increase in what type of receptor?

Answer 21

a 5-Ht1utoreceptors in the raphe nucleus

Question 22

Moncrief:

Answer 22

may not be a link between serotonin and depression

Question 23

5-HT2CR knock out is associated with what affect on appetite?

Answer 23

an increase

Question 24

Lorcaserin is an agonist for which receptor?

Answer 24

5-HT2C

Question 25

binding of lorcaserin to 5-HT2C receptors causes what change to weight?

Answer 25

a decrease

Question 26

why was lorcaserin no longer FDA-approved in 2020?

Answer 26

slightly increases cancer incidence

Question 27

reuptake inhibitors had what effect on emotional aversion to harm?

Answer 27

increases it

Question 28

describe the connection between PTSD and serotonin.

Answer 28

increase in 5-HT1A receptors in PTSD group

Question 29

how did MDMA along with therapy differ from therapy on its own in PTSD treatment?

Answer 29

combined treatments resulted in more: remission, loss of the diagnosis, and responders

Question 30

which serotonin receptor is implicated in OCD?

Answer 30

5-HT7

Question 31

variations of SERT in OCD

Answer 31

genetic epigenetic (methylation)

Question 32

genetic connotations in OCD involve

Answer 32

gender and age of onset

Question 33

which serotonin receptor is implicated in Alzheimers treatment?

Answer 33

5-HT4

Question 34

5-HT4 receptors are involved in which pathway?

Answer 34

non-amyloidogenic

Question 35

implication of 5-HT4 receptor in alzheimers

Answer 35

activation stimulates ADAM-10 which cleaves APP

Question 36

which drugs may be beneficial in alzheimers treatment

Answer 36

5-HT4 agonists

Question 37

selective 5-HT4 agonists bring about what effects?

Answer 37

reduction in plaques increase in sAPP alpha decreases inflammation better cognition

Question 38

selective 5-HT4 agonists improve function of which brain region?

Answer 38

hippocampus

Question 39

behavioral functions of serotonin

Answer 39

temperature regulation sleep and wake cycle ibs pain