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Neurobiology > Lecture 14, drugs affecting serotonin > Flashcards

Lecture 14, drugs affecting serotonin Flashcards

1
Q

why are 5Ht1 receptors inhibitory?

A

coupled to Gi/Go proteins which inhibit cAMP formation

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2
Q

how does binding to 5-HT1 trigger hyperpolarisation?

A

activates GiRK

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3
Q

along with 5-HT1A, which other receptor reduces serotonin release upon activation?

A

5-HT1B

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4
Q

what is the effect of 5-HT1A and 5HT1b receptors on non-serotonergic receptors?

A

inhibit release of other neurotransmitters

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5
Q

5-Ht1A/b receptor location

A

post and pre synaptically

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6
Q

which channels are activated upon activation of 5-Ht1a/B receptors on post-synaptic membrane?

A

GiRk

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7
Q

migranes can be treated with

A

serotonin receptor agonists

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8
Q

how does sumatriptan exert its effects?

A

binds to presynaptic 5-HT1 receptors to inhibit proinflammatory peptide and neuropeptide release
binds post-synaptically to trigger vasoconstriction

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9
Q

why is Lasmiditan suitable in treating migraines in those with vascular disease?

A

doesnt trigger vasoconstriction

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10
Q

which drug targets 5-HT1F receptors

A

Lasmiditan

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11
Q

migraine involved the activation of which sensory nerves?

A

trigeminal

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12
Q

activation of 5-Ht3 receptors causes what movement?

A

inward movement of K, Na and Ca

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13
Q

release of serotonin, CCK, gabba and dopamine is triggered by activation of what kind of serotonin receptor?

A

presynaptic 5-HT3

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14
Q

where are post synaptic 5-HT3 receptors located?

A

hippocampus

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15
Q

how does ondansetron prevent drug-induced vomiting

A

5-HT3 receptor antgagonist
prevents activation vagal afferents in periphery

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16
Q

which central regions does ondanestron prevent the activation of in response to a cytotoxic drug?

A

area postrema and the nucleus tractus solitatus- vomiting centre not innervated

17
Q

why do SSRis cause an initial decrease in mood?

A

serotonin increase in the synaptic cleft activates autoreceptors which decreases serotonin release

18
Q

SSRIS inhibit

A

SERT

19
Q

activation of autoreceptors effect on 5HT

A

decrease levels
which decreases sensitivity of autoreceptors

20
Q

decreases amount of 5ht metabolites have been associated with

A

suicide and aggression

21
Q

low serotonin revels in those who tried to kill themseleves may be due to an increase in what type of receptor?

A

a 5-Ht1utoreceptors in the raphe nucleus

22
Q

Moncrief:

A

may not be a link between serotonin and depression

23
Q

5-HT2CR knock out is associated with what affect on appetite?

A

an increase

24
Q

Lorcaserin is an agonist for which receptor?

A

5-HT2C

25
Q

binding of lorcaserin to 5-HT2C receptors causes what change to weight?

A

a decrease

26
Q

why was lorcaserin no longer FDA-approved in 2020?

A

slightly increases cancer incidence

27
Q

reuptake inhibitors had what effect on emotional aversion to harm?

A

increases it

28
Q

describe the connection between PTSD and serotonin.

A

increase in 5-HT1A receptors in PTSD group

29
Q

how did MDMA along with therapy differ from therapy on its own in PTSD treatment?

A

combined treatments resulted in more: remission, loss of the diagnosis, and responders

30
Q

which serotonin receptor is implicated in OCD?

A

5-HT7

31
Q

variations of SERT in OCD

A

genetic
epigenetic (methylation)

32
Q

genetic connotations in OCD involve

A

gender and age of onset

33
Q

which serotonin receptor is implicated in Alzheimers treatment?

A

5-HT4

34
Q

5-HT4 receptors are involved in which pathway?

A

non-amyloidogenic

35
Q

implication of 5-HT4 receptor in alzheimers

A

activation stimulates ADAM-10 which cleaves APP

36
Q

which drugs may be beneficial in alzheimers treatment

A

5-HT4 agonists

37
Q

selective 5-HT4 agonists bring about what effects?

A

reduction in plaques
increase in sAPP alpha
decreases inflammation
better cognition

38
Q

selective 5-HT4 agonists improve function of which brain region?

A

hippocampus

39
Q

behavioral functions of serotonin

A

temperature regulation
sleep and wake cycle
ibs
pain

Neurobiology (9 decks)

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